BACKGROUND: Hyperbaric oxygen therapy (HBOT) is used as a treatment for acute wounds (such as those arising from surgery and trauma). However, the effects of HBOT on wound healing are unclear. OBJECTIVES: To determine the effects of HBOT on the healing of acute surgical and traumatic wounds. SEARCH METHODS: …

The effect of nocturnal haemodialysis on body composition. Different studies show that malnutrition is a big problem in dialysis patients. There is a lot of malnutrition and poor physical functioning what results in a decline in muscle and fat tissue. Nocturnal haemodialysis has a lot of benefits, several …

Synthetic glucocorticoids are potent anti-inflammatory drugs but show dose-dependent metabolic side effects such as the development of insulin resistance and obesity. The precise mechanisms involved in these glucocorticoid-induced side effects, and especially the participation of adipose tissue in this …

Cancer is a worldwidehuman health problem.This is why much effortis put in finding solutions and treatments for this disease. One of the emerging adjuvant cancer treatments, hyperthermia, is applied by heating the tumourtissue, and is shown to increase the effects of radio and/ or chemotherapy. Because …

Achtergrond: Vooralsnog is er geen behandeling bekend welke genezing van artrose kan geven. Vanuit de literatuur zijn er aanwijzingen dat het zinvol is de biomechanische toestand van het artrotische gewricht te herstellen. Met gewrichtsdistractie bij knie- en enkelartrose wordt gepoogd, door middel van …

SAMENVATTING Achtergrond: Femoroacetabulair impingement, kortweg FAI, ontstaat wanneer er een frequent abnormaal contact is tussen het proximale deel van het femur (de kop van het heupgewricht) en het acetabulum (de kom). Dit kan komen door extra botgroei op het femur (CAM-type FAI) of op het acetabulum …

Achtergrond: Decubitus is een ernstige complicatie bij dwarslaesiepatiënten. Een dwarslaesiepatiënt heeft tot 85% kans decubitus te ontwikkelen in zijn of haar leven. Druk of druk in combinatie met schuifkrachten veroorzaken beschadigingen van de huid en onderliggend weefsel, meestal op sacrum (43%), …

Optical Coherence Tomography (OCT) is an imaging technique for collecting depth resolved information in human tissue based on an interferometer. With an imaging depth of between 1 and 2 mm, OCT is only used to investigate (near) surfaces. But with an axial (depth) resolution of between 2 and 10 μm, and …

Glucocorticoids (GCs) such as prednisolone are potent immunosuppressive drugs but suffer from severe adverse effects, including the induction of insulin resistance. Therefore, development of so-called Selective Glucocorticoid Receptor Modulators (SGRM) is highly desirable. Here we describe a non-steroidal …

Previous research has shown clinical effectiveness of dermal substitution; however, in burn wounds, only limited effect has been shown. A problem in burn wounds is the reduced take of the autograft, when the substitute and graft are applied in one procedure. Recently, application of topical negative …