Wereldwijd neemt het aantal wonden toe, hierdoor wordt er steeds meer wondzorg verleend. In Nederland stijgt het aantal zorgvragers met wondzorg. Meer dan de helft van deze wonden bevinden zich in de thuissituatie. Om wonden te beoordelen en monitoren, worden wondzorgmodellen ingezet. Binnen thuiszorgorganisatie …

Introduction: Patients with cancer receiving radio- or chemotherapy undergo many immunological stressors. Chronic regular exercise has been shown to positively influence the immune system in several populations, while exercise overload may have negative effects. Exercise is currently recommended for …

Summary: Xpaths is a collection of algorithms that allow for the prediction of compound-induced molecular mechanisms of action by integrating phenotypic endpoints of different species; and proposes follow-up tests for model organisms to validate these pathway predictions. The Xpaths algorithms are applied …

Aim: To investigate the effects of exercise on salivary concentrations of inflammatory markers by analyzing a panel of 25 inflammatory markers in subjects who had participated in bicycle ergometer tests varying in workload and hydration status. Methods: Fifteen healthy young men (20-35 years) had performed …

Een beweegbaan als motoriektest voor schoolleerlingen tussen de 12-15 jaar is er nog niet. Echter is gebleken dat de motoriek binnen deze leeftijdsgroep nog volop in ontwikkeling is. Dit onderzoek richt zich op de vraag of het mogelijk is een extra beweegbaan aan de huidige MQ scan toe te voegen die …

Op welke wijze kunnen verpleegkundigen in samenspraak met artsen mede zorgdragen aan het regelmatig bespreekbaar maken en initiëren van beslissingen rondom het reanimatiebeleid bij kwetsbare ouderen?

Adverse Outcome Pathways (AOPs) are conceptual frameworks that tie an initial perturbation (molecular initiat- ing event) to a phenotypic toxicological manifestation (adverse outcome), through a series of steps (key events). They provide therefore a standardized way to map and organize toxicological …

IL22 is an important cytokine involved in the intestinal defense mechanisms against microbiome. By using ileum-derived organoids, we show that the expression of anti-microbial peptides (AMPs) and anti-viral peptides (AVPs) can be induced by IL22. In addition, we identified a bacterial and a viral route, …

Implementation of reliable methodologies allowing Reduction, Refinement, and Replacement (3Rs) of animal testing is a process that takes several decades and is still not complete. Reliable methods are essential for regulatory hazard assessment of chemicals where differences in test protocol can influence …

The thoracic and peritoneal cavities are lined by serous membranes and are home of the serosal immune system. This immune system fuses innate and adaptive immunity, to maintain local homeostasis and repair local tissue damage, and to cooperate closely with the mucosal immune system. Innate lymphoid cells …