BACKGROUND: Paratonia is a progressive motor problem that is observed in individuals with dementia and is not a well-known phenomenon. This study explores the development and risk factors of paratonia in moderate stage dementia patients. METHODS: A multi-center, longitudinal, one-year follow-up cohort …

Background: G-protein coupled receptors (GPCRs) are involved in many different physiological processes and their function can be modulated by small molecules which bind in the transmembrane (TM) domain. Because of their structural and sequence conservation, the TM domains are often used in bioinformatics …

BACKGROUND: Prednisolone and other glucocorticoids (GCs) are potent anti-inflammatory and immunosuppressive drugs. However, prolonged use at a medium or high dose is hampered by side effects of which the metabolic side effects are most evident. Relatively little is known about their effect on gene-expression …

INTRODUCTION: It is difficult to adjust fluid balance adequately in patients with severe burns due to various physical changes. B-type natriuretic peptide (BNP) is emerging as a potential marker of hydration state. Proteinuria is used as a predictor of outcome in severe illness and might correlate to …

BACKGROUND: Burn survivors are frequently faced with disfiguring scars. Various techniques exist to improve scar appearance, such as laser treatment and dermabrasion. Next to that, surgical reconstruction, such as scar excision is an option. This randomized controlled trial investigates whether a larger …

We investigate whether the automatic generation of questions from an ontology leads to a trustworthy determination of a situation. With our Situation Awareness Question Generator (SAQG) we automatically generate questions from an ontology. The experiment shows that people with no previous experience …

Introduction Nowadays, humans are used to sit a lot during daily activities. Most of the time this happens in a relaxed way. This position is also called ´slouching´ or ´slouched posture´. In the slouched posture the pelvis and the lumbar spine are flexed and places the muscle spindles, muscles and ligaments …

Journalists in the 21st century are expected to work for different platforms, gather online information, become multi‐media professionals, and learn how to deal with amateur contributions. The business model of gathering, producing and distributing news changed rapidly. Producing content is not enough; …

Although sustainability is often discussed solely in ecological terms, it cannot be disconnected from the way humans behave in their social environment. This article presents a theoretical approach toward sustainability that takes a human behavior and knowledge view on sustainability as a starting point. …

The scientific literature represents a rich source for retrieval of knowledge on associations between biomedical concepts such as genes, diseases and cellular processes. A commonly used method to establish relationships between biomedical concepts from literature is co-occurrence. Apart from its use …