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Zocht je misschien: flooren, figuren?

Exploring needs and requirements for a prototype device measuring physical activity in pediatric physical therapy

Engels, Barbara; Kloek, Corelien J. J.; Sol, Marleen E.; Bolster, Eline A. M.; Kotte, Elles M. W.; Wittink, Harriët; Engelbert, Raoul H. H. (Urban Vitality (Fg/Fbsv)); Gorter, Jan Willem; Bloemen, Manon A. T.

Aims To analyze needs and requirements of Pediatric Physical Therapists (PPTs), parents, children and adolescents with and without developmental disabilities in the future use of an activity monitor prototype (AM-p) in everyday clinical practice. Methods Qualitative exploratory study with a thematic …

2024AlgemeenArtikel

Examining determinants of lifestyle interventions targeting persons with intellectual disabilities supported by healthcare organizations

Steenbergen, Henderika A.; de Jong, Brenda I.; Fleuren, Margot A.H.; van der Schans, Cees P.; Waninge, Aly (Participation And Health Of Persons With Intellectual And Visual Disabilities)

BACKGROUND: Due to complex processes of implementation of innovations aimed at persons with intellectual disabilities in healthcare organizations, lifestyle interventions are not used as intended or not used at all. In order to provide insight into determinants influencing this implementation, this study …

2019-07Recreatie, Beweging & Sport; …Artikel

Examining determinants of lifestyle interventions targeting persons with intellectual disabilities supported by health care organizations: usability of the MIDI

Steenbergen, Rianne; de Jong, Brenda; Fleuren, Margot; van der Schans, Cees; Waninge, Aly (Participation And Health Of Persons With Intellectual And Visual Disabilities)

Background: Due to complex processes of implementation of innovations aimed at persons with intellectual disabilities in healthcare organizations, lifestyle interventions are not used as intended or not used at all. In order to provide insight into determinants influencing this implementation, this study …

2019Recreatie, Beweging & Sport; …Artikel

Imaging Spectroscopy in the Tokamak a Configuration Variable

Martijn Fleuren (Student); R. Buning (Begeleider)

The purpose of this report is to assess the relevance of the measurement of the spectrally resolved distribution of radiation in tokamak boundary plasmas. This assessment is important and urgent in view of the recent ambition to design and construct a multi-camera configuration for hyper imaging spectroscopy1 …

2015TechniekBachelor

Prednisolone induces the Wnt signalling pathway in 3T3-L1 adipocytes

Fleuren, Wilco W M; Linssen, Margot M L; Toonen, Erik J M; van der Zon, Gerard C M; Guigas, Bruno; de Vlieg, Jacob; Dokter, Wim H A; Ouwens, D Margriet; Alkema, Wynand

Synthetic glucocorticoids are potent anti-inflammatory drugs but show dose-dependent metabolic side effects such as the development of insulin resistance and obesity. The precise mechanisms involved in these glucocorticoid-induced side effects, and especially the participation of adipose tissue in this …

2013-03-19AlgemeenArtikel

Identification of new biomarker candidates for glucocorticoid induced insulin resistance using literature mining

Fleuren, Wilco WM; Toonen, Erik JM; Verhoeven, Stefan; Frijters, Raoul; Hulsen, Tim; Rullmann, Ton; van Schaik, René; de Vlieg, Jacob; Alkema, Wynand

Background: Glucocorticoids are potent anti-inflammatory agents used for the treatment of diseases such as rheumatoid arthritis, asthma, inflammatory bowel disease and psoriasis. Unfortunately, usage is limited because of metabolic side-effects, e.g. insulin resistance, glucose intolerance and diabetes. …

2013-02-04AlgemeenArtikel

Molecular pathway profiling of T lymphocyte signal transduction pathways; Th1 and Th2 genomic fingerprints are defined by TCR and CD28-mediated signaling

Smeets, Ruben L; Fleuren, Wilco W M; He, Xuehui; Vink, Paul M; Wijnands, Frank; Gorecka, Monika; Klop, Henri; Bauerschmidt, Sussane; Garritsen, Anja; Koenen, Hans J P M; Joosten, Irma; Boots, Annemieke M H; Alkema, Wynand

BACKGROUND: T lymphocytes are orchestrators of adaptive immunity. Naïve T cells may differentiate into Th1, Th2, Th17 or iTreg phenotypes, depending on environmental co-stimulatory signals. To identify genes and pathways involved in differentiation of Jurkat T cells towards Th1 and Th2 subtypes we performed …

2012-03-14AlgemeenArtikel

ss-TEA

umc, radboud; Fleuren, Wilco W M; Verhoeven, Stefan; van den Beld, Sven; Alkema, Wynand; de Vlieg, Jacob; Klomp, Jan P G

Background: G-protein coupled receptors (GPCRs) are involved in many different physiological processes and their function can be modulated by small molecules which bind in the transmembrane (TM) domain. Because of their structural and sequence conservation, the TM domains are often used in bioinformatics …

2011-08-10AlgemeenArtikel

Prednisolone-induced changes in gene-expression profiles in healthy volunteers

Toonen, Erik J M; Fleuren, Wilco W M; Nässander, Ulla; van Lierop, Marie-José C; Bauerschmidt, Susanne; Dokter, Wim H A; Alkema, Wynand

BACKGROUND: Prednisolone and other glucocorticoids (GCs) are potent anti-inflammatory and immunosuppressive drugs. However, prolonged use at a medium or high dose is hampered by side effects of which the metabolic side effects are most evident. Relatively little is known about their effect on gene-expression …

2011-07-25AlgemeenArtikel

CoPub update

Fleuren, Wilco W M; Verhoeven, Stefan; Frijters, Raoul; Heupers, Bart; Polman, Jan; van Schaik, René; de Vlieg, Jacob; Alkema, Wynand

In this article, we present CoPub 5.0, a publicly available text mining system, which uses Medline abstracts to calculate robust statistics for keyword co-occurrences. CoPub was initially developed for the analysis of microarray data, but we broadened the scope by implementing new technology and new …

2011-05-27AlgemeenArtikel

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