The architecture of TP 53 , the most frequently mutated gene in human cancer, is more complex than previously thought. Using TP 53 variants as clinical biomarkers to predict response to treatment or patient outcome requires an unequivocal and standardized procedure toward a definitive strategy for the …

BACKGROUND: Muscle force is important for daily life and sports and can be measured with a handheld dynamometer. Reference values are employed to quantify a subject's muscle force. It is not unambiguous whether reference values can be generalized to other populations. Objectives in this study were; first …

PURPOSE: To determine the impact of late radiation-induced toxicity on health-related quality of life (HRQoL) among patients with prostate cancer. PATIENTS AND METHODS: The study sample was composed of 227 patients, treated with external beam radiotherapy. Common Terminology Criteria for Adverse Events …

Small RNAs are important regulators of genome function, yet their prediction in genomes is still a major computational challenge. Statistical analyses of pre-miRNA sequences indicated that their 2D structure tends to have a minimal free energy (MFE) significantly lower than MFE values of equivalently …

Fragmentation of the environment affects the dispersal of Eurasian lynx (Lynx lynx). This also occurs in the Harz region, in central Germany, where in 2000 the Luchsprojekt Harz started reintroducing the Eurasian lynx. This constantly growing population causes lynx dispersal including high traffic volume …

As an essential basic principle of the European Union, the free movement of workers has been on everyone’s lips with the European Enlargement of Romania and Bulgaria in 2007. With the complete abolishment of the restrictions on the free movement of workers for Romanian and Bulgarian citizens in Germany …

In the following paper I investigate several factors of integration and their influence on students’ success in higher education derived from leading pedagogical theories. Furthermore the use of Facebook by first year students, in the Department of Media, Communication and Information at the Amsterdam …

Bioelectrical impedance analysis (BIA) may be used to assess fat free mass (FFM) with reasonable validity based on mean-level comparisons, but differences between BIA and DXA may vary by about 4 kg in an individual patient. These results require confirmation in a larger sample of HNC (Head and neck cancer) …

BACKGROUND: The predictive validity of the Low Back Pain Perception Scale is determined in two studies in general practice and showed sufficient discriminative ability, although the psychometric properties of the scale have never been established until now. OBJECTIVE: To determine the reliability and …

Background: Haemodialysis patients have a high risk of malnutrition which is associated with increased mortality. Nocturnal haemodialysis (NHD) is associated with a significant increase in protein intake compared with conventional haemodialysis (CHD). It is unclear whether this leads to improved nutritional …