Clonal haematopoiesis of intermediate potential (CHIP) driven by somatic mutations in DNMT3A and TET2 has been recently recognized as a new risk factor for cardiovascular diseases (CVD). The haematopoietic clones with mutations in these genes are frequently found in myeloid malignancies and according …

Diabetes remains a major risk for atherosclerotic-cardiovascular disease (CVD). While many mechanisms have been explored, the full extent of how diabetes promotes CVD remains unknown. An emerging area in diabetes is the influence of epigenetic regulation of gene expression. Diabetes has been shown to …

Local online retail platforms (LORPs) are gaining popularity as digital channels that can increase physical retail agglomerations’ attractiveness and viability by stimulating online sales and consumer footfall. However, insights are needed to enrich academic understanding and guide practitioners in their …

Anthropogenic changes to estuaries, usually highly productive systems, may result in increased turbidity levels, suppress pelagic primary production and negatively affect ecosystem functions. The Ems-Dollard estuary, enclosed between the Netherlands and Germany, is such an estuary with a long history …

Summary: Xpaths is a collection of algorithms that allow for the prediction of compound-induced molecular mechanisms of action by integrating phenotypic endpoints of different species; and proposes follow-up tests for model organisms to validate these pathway predictions. The Xpaths algorithms are applied …

Background: Adverse outcome pathway (AOP) networks are versatile tools in toxicology and risk assessment that capture and visualize mechanisms driving toxicity originating from various data sources. They share a common structure consisting of a set of molecular initiating events and key events, connected …

The nonlinearity induced by light-emitting diodes in visible light communication (VLC) systems presents a challenge to the parametrization of orthogonal frequency division multiplexing (OFDM). The goal of the multi-objective optimization problem presented in this study is to maximize the transmitted …

Floating photovoltaics (FPV) is emerging as a promising renewable energy technology which enables the production of electricity on surface waters. While this technology could potentially make an important contribution to the energy transition, the current uncertainty about the water quality effects of …

Food insecurity remains a critical challenge, especially for developing countries like Kenya. While factors such as high poverty rate, rural-urban migration, pandemics including Covid-19, desert locusts, etcetera remain part of immediate causes, shocks resulting from climate change, such as drought, …

The dynamic inflow effect describes the unsteady aerodynamic response to fast changes in rotor loading due to the inertia of the wake. Fast changes in turbine loading due to pitch actuation or rotor speed transients lead to load overshoots. The phenomenon is suspected to be also relevant for gust situations; …