Background: Immune-related adverse drug reactions (ADRs) to immunotherapy agents have been associated with beneficial clinical outcomes in oncology. Viscum album L. (VA, European mistletoe) is frequently used as an immunomodulatory agent alongside conventional cancer treatment in Europe. VA has been …

Eighteen years after the introduction of the graphing calculator in national examinations in the Netherlands, much has been learned about the use of technology in education. One of the key lessons was that integrating ICT as a tool for learning math is a complex task, and this complexity is often underestimated. …

In the present study, how crime scene investigators are informed before going to a crime scene was investigated. In order to gain more insight in the flow of information from emergency call to crime scene, semi-structured interviews were conducted in three different police regions with six crime scene …

Aim: To explore 1) GPs´ motivation to refer to lifestyle interventions and to investigate the association between GPs’ own lifestyle-behaviors and their referral behavior, and 2) patient indicators in the decision-making process of the GPs’ referral to lifestyle interventions. Method: A cross-sectional …

Insufficient physical activity or being inactive is one of the leading risk factors for non-communicable diseases worldwide. Globally between 6-10% of premature mortality, caused by non-communicable diseases, could be avoided if people adhered to general physical activity guidelines. Besides that, studies …

Objective In order to deliver good healthcare quality, it should explicitly be taken into account what patients value in healthcare. This study reviews qualitative studies in which patients express what they value. Based on this body of literature a preliminary taxonomy is designed. Methods A systematic …

Purpose: The etiology of pain in osteoarthritis (OA) is complex and multifactorial. A growing number of studies suggest that modification of pain-transmission in the peripheral and central nervous system, leading to sensitization, plays a role in OA pain. Sensitization seems to be associated with neuropathic …

The additive manufacturing (AM) of high-quality products requires knowledge of the 3D-printing process and the related design guidelines. Allthough AM has been around for some years, many engineers still lack this knowledge. Therefore, Fontys University of Applied Sciences sets great store by training …

In this chapter, we propose an ethical framework for serious game design, which we term the Ecosystem for Designing Games Ethically (EDGE). EDGE expands on Zagal’s categorization of ethical areas in game design by incorporating the different contexts of design and their use. In addition, we leverage …