Effects of systemic inflammation on cerebral function are not clear, as both inflammation-induced encephalopathy as well as stress-hormone mediated alertness have been described. Experimental endotoxemia (2 ng/kg Escherichia coli lipopolysaccharide [LPS]) was induced in 15 subjects, whereas 10 served …

"Alles goed regelen, o zeker, maar wanneer begin je daarmee?" Op je 50e of 60e kun je van alles regelen, zodat je kinderen dat niet hoeven doen. Misschien wordt je wel 70 of 80. Of erger nog, 90... …

A psycho-organic disorder such as delirium is a frequently occurring and serious disorder especially on Intensive Care units. Nowadays, more attention is paid to this problem by physicians, nurses and by researchers, but assessment of delirium in all ICU patients is still not common practice. If patients …

In de zomer van 2010 bracht de HEMA een site in de lucht waarop spiektips konden worden geplaatst. De site kreeg veel aandacht in de media en leidde tot ophef. Docenten werden door de Onderwijsraad opgeroepen kennis te nemen van alle spiektips. Moet spieken als fraude worden gezien of als iets onschuldigs? …

The use of patterns in a design process, including data modeling, is an attempt to create a better solution to a problem. We propose the use of data model patterns, organized in a pattern language, and based on Fully Communication Oriented Information Modeling (FCO-IM) as the modeling approach, as a …

Zelfsturing in organisaties betekent werken met teams die gezamenlijken zoveel mogelijk zelfstandig werken aan de totstandkoming van eenproduct of dienst. In deze reportage wordt onderzocht welke consequenties dat heeft voor leren en opleiden. …

This article describes a blueprint for an online learning environment that is based on prominent instructional design and assessment theories for supporting learning in complex domains. The core of this environment consists of formative assessment tasks (i.e., assessment for learning) that center on …

It may be true (but confirmation is required) that adding delirium to a measurement such as the APACHE score is not of value. Clinicians and hospital quality officers should continue to consider early detection of delirium and ongoing delirium detection as an important prognostic tool. Despite shortcomings …

De beleidsdiscussies over kennis en innovatie worden gedomineerd door dogma’s en axioma’s die zelden geëxpliciteerd worden. Het is daarom goed om bij het begin te beginnen. In 29 observaties schetst Dany Jacobs hoe de wereld van innovatie eruit ziet en welk soort kennis daarbij vereist is. Wat betekent …

The past few months have involved becoming acquainted and more familiar with the creative industries in the various regions of the Organza partners. Dany Jacobs (ARCCI – Arnhem Centre for Creative Economy and Innovation) reports. I had already known for some time that both Nottingham and Treviso were …