It is estimated that over 30,000 lesions in the DNA are generated per cell per day. In S-phase, lesions in the DNA can stall replication, which can lead to secondary lesions such as DNA double- strand breaks. The DNA damage tolerance (DDT) network enables replication to be continued in the presence of …

In 2013, the Joint Action Plan for Mental Health and Well-being (JA-MH-WB) was launched as a collaborative effort by the European Union and the 28 Member States. It aims were to build a framework for action mental health policy at the European level and builds on previous work developed under the European …

The current configuration of the robotic stearate coating process only supports certain bead sizes, the rest is coated manually. The current configuration lacks capacity and requires a lot of maintenance due to the age of the used robots. To be able to support all bead sizes, increase the daily capacity, …

The crossroads of living in cities on the one hand and ageing of the population on the other is studied in an interdisciplinary field of research called urban ageing (van Hoof and Kazak 2018, van Hoof et al. 2018). People live longer and in better health than ever before in Europe. Despite all the positive …

On duty, police officers are exposed to a variety of acute, threatening stress situations and organizational demands. In line with the allostatic load model, the resulting acute and chronic stress might have tremendous consequences for police officers’ work performance and psychological and physical …

Immense beyond imagination, the untamed rainforests of western New Guinea represent a biodiversity hotspot, home to several unique species of flora and fauna. The territory’s astonishing beauty and diversity is underpinned by a stunning array of natural resources. The island is also home to many indigenous …

E-Exercise is an effective 12-week blended intervention consisting of around five face-to-face physiotherapy sessions and a web-based application for patients with hip/knee osteoarthritis. In order to facilitate effective implementation of e-Exercise, this study aims to identify physiotherapists' experiences …

How can transport and land-use transitions in urban regions be understood and supported? This question is increasingly relevant for researchers and policy makers alike given the growing urgency of sustainability issues confronting cities and the limited improvements can be observed despite continued …

The goal of this research is to examine the differences between the Netherlands and Germany, when it comes to European integration. The central question in this thesis is: “Why do the Netherlands and Germany differ on further European integration?”. Through desk research and field research, in the form …