Nicotine is a well-known and highly addictive substance with complex effects on cognition, anxiety, and neurophysiology. Despite its short-term anxiolytic effects, this drug often exacerbates anxiety symptoms. It disrupts emotional regulation through its impact on the central nucleus of the amygdala …

Brain disorders, such as Alzheimer’s disease and epilepsy have been linked to an imbalance in excitatory and inhibitory (E/I) inputs in the brain. However, the molecular mechanisms underlying E/I balance and plasticity in the brain are largely unresolved. Inhibitory synapses have a strong impact on brain …

Inleiding: Jaarlijks houden 40.000 mensen blijvende beperkingen over na hersenletsel, waaronder een Cerebrovasculair Accident (CVA). Voor het herstel van CVA-patiënten wordt bij Roessingh Centrum voor Revalidatie spiegeltherapie ingezet middels een protocol. Het doel is om een advies op te stellen voor …

Alzheimer's disease is a complex neurodegenerative disease and the most prevalent form of dementia. It affects every 14th person after the age of 65, thus making it a serious concern in modern society. Furthermore, currently available treatment is restricted only to symptomatic and is not highly effective. …

Autism Spectrum Disorder (ASD) is a neurobiological condition affecting about 1% of the population, characterized by repetitive behaviors, restricted interests, and communication deficiencies. While ASD has both genetic and environmental influences, the role heritable yet non genetic gastrointestinal …

Continuous brain function monitoring in a pediatric intensive care unit is often done using electroencephalography (EEG) for the detection of epileptic seizures in comatose patients. Monitoring an EEG is a time-intensive task for medical professionals, especially when the seizures manifest in a subtle …

Over time memories are believed to undergo a time-dependent reorganization in the brain through a process known as systems consolidation during which they become less dependent on the hippocampus and more dependent on the neocortical structures. This reorganization is accompanied by a generalization …

Het geweld dat afkomstig is uit de georganiseerde misdaad is een significant probleem in het noorden van de staat Tamaulipas. Deze staat grenst aan de Verenigde Staten en wordt geteisterd door geweld, ontvoeringen, drugssmokkel, afpersingen en mensensmokkel. Er is weinig academisch onderzoek gedaan naar …

Balance deficits play a major role in patients who have suffered strokes. It is estimated that 30% of patients cannot walk independently 6 months post-stroke, usually caused by impaired standing balance due to hemiplegia or hemiparesis that is experienced. Balance as a whole is a key factor when it comes …

SMPD4 is a neutral sphingomyelinase that plays an important role in sphingolipid metabolism. Sphingolipids are a family of lipid molecules abundantly present in the brain where they play an important role in the brain development and function due to their essential cellular role as structural components …