Accurate assessment of TP53 gene status in sporadic tumors and in the germline of individuals at high risk of cancer due to Li–Fraumeni Syndrome (LFS) has important clinical implications for diagnosis, surveillance, and therapy. Genomic data from more than 20,000 cancer genomes provide a wealth of information …

The thesis project was devoted to a differentiation of different types of cancer cells checking the effectiveness of the novel anti-leukemia chemicals and exploring whether the best anti-leukemia targets also target bone cancers. The research question of this project is as follows: “How leukemia and …

‘De Verse Maaltijd’ is a leading company of different food concepts. The company is specialized in the preparation of fresh and healthy meals for different target groups. The new concept of De Verse Maaltijd, DinnerFresh, is a slightly different and very challenging. This concept offers fresh and healthy …

BACKGROUND: Nurse-coordinated care (NCC) improves the achievement of low-density lipoprotein-cholesterol (LDL-C) targets after an acute coronary syndrome (ACS). We hypothesised that NCC improves achievement of LDL-C targets through more intensive medication titration. METHODS: We used data from Randomised …

This study seeks to explore the characteristics of cyber-organised crime (OC), and focuses on the criminal activities of cyber-OC groups, their modus operandi, the organisational structures, the ‘profiles’ of the involved offenders, and the characteristics of criminal investigation into these cases. …

This article proposes a strategy for Switzerland to change the goal from HIV control to HIV elimination. In Switzerland, HIV treatment is well organized and available for all with good access. An important challenge that obstructs prevention is the new infections originating from people who are unaware …

OBJECTIVE: To describe professionals' perceptions of factors that facilitate or hamper the implementation and continuation of a physical activity promotion programme in rehabilitation. DESIGN: This study used a qualitative design. METHODS: Semi-structured interviews (n = 22) were conducted with rehabilitation …

This study was conducted for IES Asset Management BV. The reason for this study is that IES has no insight into their sales forecast. Due to the regular ongoing work activities, the focus on sales targets can be forgotten. IES would like to have more insight and understanding in their revenue predictability. …

While in business and private settings the disruptive impact of advanced information communication technology (ICT) have already been felt, the legal sector is now starting to face great disruptions due to such ICTs. Bits and pieces of innovations in the legal sector have been emerging for some time, …

It is often assumed that ‘evaluation’ is about judging or assessing a particular piece of practice or intervention, for example after an initial pilot stage to determine whether to continue, or at the end of a programme of work to determine the impact on client behaviour and recidivism. What may be considered …