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Prednisolone induces the Wnt signalling pathway in 3T3-L1 adipocytes

Fleuren, Wilco W M; Linssen, Margot M L; Toonen, Erik J M; van der Zon, Gerard C M; Guigas, Bruno; de Vlieg, Jacob; Dokter, Wim H A; Ouwens, D Margriet; Alkema, Wynand

Synthetic glucocorticoids are potent anti-inflammatory drugs but show dose-dependent metabolic side effects such as the development of insulin resistance and obesity. The precise mechanisms involved in these glucocorticoid-induced side effects, and especially the participation of adipose tissue in this …

2013-03-19AlgemeenArtikel

Program-involvement effects on commercial attention and recall of successive and embedded advertising

M. Moorman; L.M. Willemsen (Lector); P.C. Neijens; E.G. Smit

Research on context effects has demonstrated a link between program-induced involvement and recall of commercials broadcast in breaks. However, the effect of program-induced involvement on recall of advertising embedded in the program itself has been understudied. In addition, little consideration has …

2013-03-08ICT & MediaArtikel

Identification of new biomarker candidates for glucocorticoid induced insulin resistance using literature mining

Fleuren, Wilco WM; Toonen, Erik JM; Verhoeven, Stefan; Frijters, Raoul; Hulsen, Tim; Rullmann, Ton; van Schaik, René; de Vlieg, Jacob; Alkema, Wynand

Background: Glucocorticoids are potent anti-inflammatory agents used for the treatment of diseases such as rheumatoid arthritis, asthma, inflammatory bowel disease and psoriasis. Unfortunately, usage is limited because of metabolic side-effects, e.g. insulin resistance, glucose intolerance and diabetes. …

2013-02-04AlgemeenArtikel

Het effect van CIMT, bimanuele therapie en de combinatie van CIMT en bimanuele therapie op de functionele handvaardigheid bij kinderen met unilaterale spastische cerebrale parese: een systematisch literatuuronderzoek

Manouk Jochem; Emma Schouten

Inleiding: Eén van de belangrijkste problemen bij kinderen met unilaterale spastische cerebrale parese (CP) is de asymmetrische ontwikkeling van de armen en de handen. Dit wordt 'developmental disregard' genoemd, oftewel het negeren en het niet spontaan inzetten van de aangedane arm en/of hand. Constraint-Induced …

2013GezondheidBachelor

Resonance enhanced laser-induced breakdown spectroscopy

Daniel Bouman (Student); C.A. Swarts (Begeleider)

Resonance-enhanced laser-induced breakdown spectroscopy was used to increase the elemental sensitivity of laser-induced breakdown spectroscopy. In resonance-enhanced laser-induced breakdown spectroscopy, two lasers are used. The first laser creates a plasma, and the second laser re excites the most …

2013TechniekBachelor

Constraint Induced Movement Therapy : use it and improve it, or lose it?

Lisa Baart

Achtergrond en doel: Volgens recent onderzoek zijn CIMT en mCIMT mogelijk goede therapieën om de hand- en armfunctie van een CVA patiënt te verbeteren. Het doel van deze literatuurstudie is om het effect van CIMT en mCIMT te vergelijken met het effect van conventionele therapieën. Methode: Zes artikelen …

2013GezondheidBachelor

Identification of biomarkers to detect residual pertussis toxin using microarray analysis of dendritic cells

R.J. Vandebriel; Saertje Verkoeijen (Lid Lectoraat); A.M. Akkermans; Stefan Vaessen (Lid Lectoraat); M.W.P. Bruysters; J.L.A. Pennings; R. Bos; Cyrille Krul (Lector)

tIn this study we aimed to identify genes that are responsive to pertussis toxin (PTx) and might eventu-ally be used as biological markers in a testing strategy to detect residual PTx in vaccines. By microarrayanalysis we screened six human cell types (bronchial epithelial cell line BEAS-2B, fetal lung …

2013Natuur & LandbouwArtikel

Org 214007-0

van Lierop, Marie-José C; Alkema, Wynand; Laskewitz, Anke J; Dijkema, Rein; van der Maaden, Hans M; Smit, Martin J; Plate, Ralf; Conti, Paolo G M; Jans, Christan G J M; Timmers, C Marco; van Boeckel, Constant A A; Lusher, Scott J; McGuire, Ross; van Schaik, Rene C; de Vlieg, Jacob; Smeets, Ruben L; Hofstra, Claudia L; Boots, Annemieke M H; van Duin, Marcel; Ingelse, Benno A; Schoonen, Willem G E J; Grefhorst, Aldo; van Dijk, Theo H; Kuipers, Folkert; Dokter, Wim H A

Glucocorticoids (GCs) such as prednisolone are potent immunosuppressive drugs but suffer from severe adverse effects, including the induction of insulin resistance. Therefore, development of so-called Selective Glucocorticoid Receptor Modulators (SGRM) is highly desirable. Here we describe a non-steroidal …

2012-11-12AlgemeenArtikel

The Pirate group intervention protocol description and a case report of a modified constraint-induced movement therapy combined with bimanual training for young children with unilateral spastic cerebral palsy

Aarts, Pauline B.; van Hartingsveldt, Margo (Faculteit Gezondheid); Anderson, Patricia G.; van den Tillaar, Ingrid; van der Burg, Jan; Geurts, Alexander C.

The purpose of this article was to describe a child-friendly modified constraint-induced movement therapy protocol that is combined with goal-directed task-specific bimanual training (mCIMT-BiT). This detailed description elucidates the approach and supports various research reports. This protocol is …

2012-06AlgemeenArtikel

Molecular pathway profiling of T lymphocyte signal transduction pathways; Th1 and Th2 genomic fingerprints are defined by TCR and CD28-mediated signaling

Smeets, Ruben L; Fleuren, Wilco W M; He, Xuehui; Vink, Paul M; Wijnands, Frank; Gorecka, Monika; Klop, Henri; Bauerschmidt, Sussane; Garritsen, Anja; Koenen, Hans J P M; Joosten, Irma; Boots, Annemieke M H; Alkema, Wynand

BACKGROUND: T lymphocytes are orchestrators of adaptive immunity. Naïve T cells may differentiate into Th1, Th2, Th17 or iTreg phenotypes, depending on environmental co-stimulatory signals. To identify genes and pathways involved in differentiation of Jurkat T cells towards Th1 and Th2 subtypes we performed …

2012-03-14AlgemeenArtikel

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