Obesity is a growing global burden with numerous significant health implications, including a higher risk of developing Alzheimer’s disease (AD). This study investigates the role of obese adipose tissue on AD pathology in male APPswe/PSEN1-dE9 (APP/PSEN-1) transgenic mice, with a focus on cognitive decline, …

Brain disorders, such as Alzheimer’s disease and epilepsy have been linked to an imbalance in excitatory and inhibitory (E/I) inputs in the brain. However, the molecular mechanisms underlying E/I balance and plasticity in the brain are largely unresolved. Inhibitory synapses have a strong impact on brain …

This thesis explores how the problem of players wanting to test out and practice the mechanics they were taught in the tutorial can be solved. The objective of this research was to discover how AI can be used to increase user engagement in this Naval Warfare game, resulting in more interest in Thales …

This study focuses on developing of a cost-effective and comprehensive physiotherapy protocol for the rehabilitation of patients with femur fractures complicated by osteomyelitis with significant muscle atrophy. The primary physiotherapeutic goal is to regain ambulatory mobility, ensure the safe progression …

Due to environmental protection efforts, there is a growing number of beavers in the Netherlands. As these animals make their burrows in the levee system they cause damage within it, increasing the risk of flooding. This paper assesses the factors which increase the risk of beaver activity within the …

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The Sloe area is an unembanked industrial port area in Zeeland. As sea levels rise, this area will experience increased flood risks. This is partly due to climate change, which is causing sea level rise to accelerate, and partly due to the area's vulnerability because it is located outside the dike ring, …

Doormiddel van interviews, vragenlijsten en literatuurstudie geeft dit onderzoeksverslag antwoord op de hoofdvraag “Op welke wijze kan dramatherapie diëtisten ondersteunen bij het begeleiden van cliënten met eetstoornissen die een terugval ervaren?”. Het onderzoek is tot stand gekomen vanuit een vraagstuk …

This qualitative study explores how digital nomads and local residents of Curacao interact and integrate with each other socially and culturally. Semi structured and in depth interviews were conducted with 18 stakeholders (6 digital nomads, 6 co working space managers and 6 local residents) to collect …

This thesis focuses on optimizing the structural design and cost efficiency of an industrial electrical room for a large-scale data center located in Eemshaven, Netherlands. The industrial hall is designed to accommodate a 5-ton gantry crane integral to the installation and maintenance of heavy electrical …