RATIONALE: To date, causal therapy is potentially available for GRIN2B-related neurodevelopmental disorder (NDD) due to loss-of-function (LoF) variants in GRIN2B, resulting in dysfunction of the GluN2B subunit-containing N-methyl-d-aspartate receptor (NMDAR). Recently, in vitro experiments showed that …

A major target of the European Green Deal is to raise the 2030 greenhouse gas emission reduction target to 55% compared to 1990. This high ambition includes an increase of the energy performance of buildings and additional generation of renewable energy in all sectors. The tertiary sector, including …

Background: Shared decision-making (SDM) is often considered the ideal for decision-making in oncology. Views of specific groups such as ethnic minorities have seldom been considered in its development. Aim: In this study we seek to assess in oncology if there is a need for adaptation of the current …

Adverse Outcome Pathways (AOPs) are conceptual frameworks that tie an initial perturbation (molecular initiat- ing event) to a phenotypic toxicological manifestation (adverse outcome), through a series of steps (key events). They provide therefore a standardized way to map and organize toxicological …

Background: Despite the compelling case for engaging parents in speech and language therapy, research indicates that speech and language therapists (SLTs) currently have a leading role in the goal-setting process of therapy for children with developmental language disorder (DLD). Therefore, we set out …

Positive Energy Districts (PEDs) have the potential of accelerating the decarbonization of urban areas and promoting scalability between cities. The development and real-world implementation of such innovative concepts can be enhanced through urban energy modelling. However, assessing PEDs can be challenging, …

The study was conducted in commission of New Industrial Order (N.I.O), a laboratory for Fashion-On-Demand based in Amsterdam. A knowledge gap in literature was identified concerning the environmental performance of On-Demand manufacturing. To fill the gap, a preliminary Life Cycle Assessment was initiated, …

Implementation of reliable methodologies allowing Reduction, Refinement, and Replacement (3Rs) of animal testing is a process that takes several decades and is still not complete. Reliable methods are essential for regulatory hazard assessment of chemicals where differences in test protocol can influence …

This research evaluates how Project-Based Learning (PBL) is implemented in the Innovative Design program that is taught at The Hague University of Applied Sciences. This paper offers insights about the way students and teachers experience PBL within this program, and how the implementation can be improved …

Formative assessment can be understood as assessment for learning rather than of learning. Research has demonstrated that formative assessment/feedback is strongly and causally related to students’ achievement in higher education. At Avans University of Applied Sciences, the first-year course Mechanics …