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The efficacy of a blended intervention to improve physical activity and protein intake for optimal physical recovery after oncological gastrointestinal and lung cancer surgery, the Optimal Physical Recovery After Hospitalization (OPRAH) trial

de Leeuwerk, Marijke; de Groot, Vincent; Dam, Suzanne ten; Kruizenga, Hinke; Weijs, Peter (Lectoraat Voeding En Beweging); Geleijn, Edwin; van der Leeden, Marike; van der Schaaf, Marike (Lectoraat Revalidatie Bij Complexe Zorg); Dickhoff, Chris; Besselink, Marc G.; Tuynman, Jurriaan B.; van Berge Henegouwen, Mark I.; Erdmann, Joris I.; Huijsmans, Rosalie J.; van der Ploeg, Hidde P.; Eskes, Anne M. (Lectoraat Patiënt- En Familieparticipatie In De Klinische Zorg); Pijnappels, Mirjam A.G.M.; van Leeuwen, Liesbeth Schuijs; Smits, Anke B.; van Dijk, Jasmijn; Grimbergen, Eva

Background: Improving physical activity, especially in combination with optimizing protein intake, after surgery has a potential positive effect on recovery of physical functioning in patients after gastrointestinal and lung cancer surgery. The aim of this randomized controlled trial is to evaluate the …

2023-11-27AlgemeenArtikel

L2026M+G2032R variant confers resistance to ROS1 tyrosine kinase inhibitors in SCL34A2-ROS1 overexpressing Ba/F3 cells through a reduced ATP binding pocket volume

Dijkhuizen, Christa (Biomolecules & Health); Korthuis, Patrick; Vilachã, Juliana F.; Smelt, Maaike; van der Wekken, Anthonie; van den Berg, Anke; Drayer, Lyndsay

Background The ROS1 G2032R mutation is the most common on-target resistance mutation in crizotinib treated ROS1-positive lung cancer patients. The aim of our study was to investigate resistance mechanisms in SCL34A2-ROS1G2032R positive Ba/F3 cells against second line treatment with lorlatinib. Methods …

2023-10-21GezondheidConferentiebijdrage

Lung Ultrasound to Determine the Effect of Lower vs. Higher PEEP on Lung Aeration in Patients without ARDS—A Substudy of a Randomized Clinical Trial

Zimatore, Claudio; Algera, Anna Geke; Botta, Michela; Pierrakos, Charalampos; Serpa Neto, Ary; Grasso, Salvatore; Schultz, Marcus J.; Pisani, Luigi; Paulus, Frederique (Lectoraat Critical Care)

Background: Ventilation with lower positive end–expiratory pressure (PEEP) may cause loss of lung aeration in critically ill invasively ventilated patients. This study investigated whether a systematic lung ultrasound (LUS) scoring system can detect such changes in lung aeration in a study comparing …

2023-06AlgemeenArtikel

Burgers met COPD samen in beweging tegen eenzaamheid:

Michelle Viveen (Student)

Aanleiding: Chronic Obstructive Lung Disease (COPD) is de derde doodsoorzaak wereldwijd. COPD zorgt voor een verminderd inspanningsvermogen en kan samen gaan met eenzaamheid. Dit kan op termijn leiden tot een verminderd inspanningsvermogen, waardoor er een negatieve spiraal ontstaat. Patiënten met COPD …

2023-05-30GezondheidMaster

A proteomics approach to identify COPD-related changes in lung fibroblasts

Bekker, Nicolaas J.; van Pijkeren, Alienke; Wolters, Justina C.; Sánchez Brotons, Alejandro; Guryev, Victor; Woldhuis, Roy R.; Bischoff, Rainer; Alkema, Wynand; Horvatovich, Peter; van Nijnatten, Johannes L.L.; van den Berge, Maarten; Timens, Wim; Brandsma, Corry-Anke

Background: Lung fibroblasts are implicated in abnormal tissue repair in chronic obstructive pulmonary disease (COPD). The exact mechanisms are unknown and comprehensive analysis comparing COPD- and control fibroblasts is lacking. Aim: To gain insight in the role of lung fibroblasts in COPD pathology …

2023-04-01AlgemeenArtikel

The correlation of muscle quantity and quality between all vertebra levels and level L3, measured with CT

Van den Broeck, Jona; Sealy, Martine J (Healthy Ageing, Allied Health Care And Nursing); Brussaard, Carola; Jager-Wittenaar, Harriët (Healthy Ageing, Allied Health Care And Nursing); Scafoglieri, Aldo; Kooijman, Jasmijn

INTRODUCTION: In patients with cancer, low muscle mass has been associated with a higher risk of fatigue, poorer treatment outcomes, and mortality. To determine body composition with computed tomography (CT), measuring the muscle quantity at the level of lumbar 3 (L3) is suggested. However, in patients …

2023-02-23AlgemeenArtikel

Effect of lung ultrasound-guided fluid deresuscitation on duration of ventilation in intensive care unit patients (CONFIDENCE)

Blok, Siebe G.; Mousa, Amne; Brouwer, Michelle G.; de Grooth, Harm-Jan; Neto, Ary Serpa; Blans, Michiel J.; den Boer, Sylvia; Dormans, Tom; Endeman, Henrik; Roeleveld, Timo; Scholten, Harm; van Slobbe-Bijlsma, Eline R.; Scholten, Erik; Touw, Hugo; van der Ven, Fleur Stefanie L. I. M.; Wils, Evert-Jan; van Westerloo, David J.; Heunks, Leo M. A.; Schultz, Marcus J.; Paulus, Frederique (Lectoraat Critical Care); Tuinman, Pieter R.

Background Fluid therapy is a common intervention in critically ill patients. It is increasingly recognised that deresuscitation is an essential part of fluid therapy and delayed deresuscitation is associated with longer invasive ventilation and length of intensive care unit (ICU) stay. However, optimal …

2023AlgemeenArtikel

Respiratory and non-respiratory symptoms in patients with IPF or sarcoidosis and controls

Aadje Bloem (Onderzoeker); Sarah Houben-Wilke (Onderzoeker); Rémy Mostard (Onderzoeker); Naomi Stoot (Onderzoeker); Daisy J. A. Janssen (Onderzoeker); Frits Franssen (Onderzoeker); Jan Custers (Onderzoeker); Martijn A. Spruit (Onderzoeker)

Introduction: Besides dyspnoea and cough, patients with idiopathic pulmonary fibrosis (IPF) or sarcoidosis may experience distressing non-respiratory symptoms, such as fatigue or muscle weakness. However, whether and to what extent symptom burden differs between patients with IPF or sarcoidosis and individuals …

2023GezondheidArtikel

Illness Perceptions and Self-Management among People with Chronic Lung Disease and Healthcare Professionals

Xiaoyue Song (Onderzoeker); Cynthia Hallensleben; Weihong Zhang; Zongliang Jiang; Hongxia Shen; Robbert Gobbens (Lector); Niels H. Chavannes; Anke Versluis

Abstract: Self-management interventions (SMIs) may fail if they misalign with the local context. To optimize the implementation of SMIs in Chinese people with chronic lung disease (CLD), the local context was identified in Chinese primary care (PC) and secondary care (SC). A mixed-method study using …

2022-08-30GezondheidArtikel

Self-monitoring of physical activity after hospital discharge in patients who have undergone gastrointestinal or lung cancer surgery

de Leeuwerk, Marijke Elizabeth; Botjes, Martine; van Vliet, Vincent; Geleijn, Edwin; de Groot, Vincent; van Wegen, Erwin; van der Schaaf, Marike (Faculteit Gezondheid); Tuynman, Jurriaan; Dickhoff, Chris; van der Leeden, Marike

BACKGROUND: Self-monitoring of physical activity (PA) using an accelerometer is a promising intervention to stimulate PA after hospital discharge. OBJECTIVE: This study aimed to evaluate the feasibility of PA self-monitoring after discharge in patients who have undergone gastrointestinal or lung cancer …

2022-06-24AlgemeenArtikel

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