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Course of recovery of respiratory muscle strength and its associations with exercise capacity and handgrip strength: A prospective cohort study among survivors of critical illness

Major, Mel (Urban Vitality); van Egmond, Maarten (Lectoraat Fysiotherapie -Bewegen Naar Preventieve Zorg); Dettling-Ihnenfeldt, Daniela; Ramaekers, Stephan (Lectoraat Fysiotherapie -Bewegen Naar Preventieve Zorg); Engelbert, Raoul (Urban Vitality); van der Schaaf, Marike (Lectoraat Revalidatie Bij Complexe Zorg)

Background Mechanical ventilation affects the respiratory muscles, but little is known about long-term recovery of respiratory muscle weakness (RMW) and potential associations with physical functioning in survivors of critical illness. The aim of this study was to investigate the course of recovery of …

2023AlgemeenArtikel

The impact of high versus standard enteral protein provision on functional recovery following intensive care admission (PRECISE trial)

van Gassel, Rob J. J.; Bels, Julia L. M.; Tartaglia, Katrien; van Bussel, Bas C. T.; van Kuijk, Sander M. J.; Deane, Adam M.; Puthucheary, Zudin; Weijs, Peter J. M. (Lectoraat Voeding En Beweging); Vloet, Lilian; Beishuizen, Bert; De Bie Dekker, Ashley; Fraipont, Vincent; Lamote, Stoffel; Ledoux, Didier; Scheeren, Clarissa; De Waele, Elisabeth; van Zanten, Arthur R. H.; Mesotten, Dieter; van de Poll, Marcel C. G.

Background Critically ill patients are subject to severe skeletal muscle wasting during intensive care unit (ICU) stay, resulting in impaired short- and long-term functional outcomes and health-related quality of life. Increased protein provision may improve functional outcomes in ICU patients by attenuating …

2023AlgemeenArtikel

The Use of Mechanical Insufflation-Exsufflation in Invasively Ventilated Critically Ill Adults

Swingwood, Ema L; Stilma, Willemke (Faculteit Gezondheid); Tume, Lyvonne N; Cramp, Fiona; Voss, Sarah; Bewley, Jeremy; Ntoumenopoulos, George; Schultz, Marcus J; Scholte Op Reimer, Wilma; Paulus, Frederique (Lectoraat Critical Care); Rose, Louise

Mechanical insufflation-exsufflation (MI-E) is traditionally used in the neuromuscular population. There is growing interest of MI-E use in invasively ventilated critically ill adults. We aimed to map current evidence on MI-E use in invasively ventilated critically ill adults. Two authors independently …

2022-08-01AlgemeenAndersoortig materiaal

Dead space estimates may not be independently associated with 28-day mortality in COVID-19 ARDS

PRoVENT-COVID Study Group

Background: Estimates for dead space ventilation have been shown to be independently associated with an increased risk of mortality in the acute respiratory distress syndrome and small case series of COVID-19-related ARDS. Methods: Secondary analysis from the PRoVENT-COVID study. The PRoVENT-COVID is …

2021-12-01AlgemeenArtikel

The impact of frailty on survival in elderly intensive care patients with COVID-19

COVIP Study Group

Background: The COVID-19 pandemic has led highly developed healthcare systems to the brink of collapse due to the large numbers of patients being admitted into hospitals. One of the potential prognostic indicators in patients with COVID-19 is frailty. The degree of frailty could be used to assist both …

2021-12-01AlgemeenArtikel

Longitudinal respiratory subphenotypes in patients with COVID-19-related acute respiratory distress syndrome

PRoVENT-COVID

INTRODUCTION: Patients with COVID-19-related acute respiratory distress syndrome (ARDS) have been postulated to present with distinct respiratory subphenotypes. However, most phenotyping schema have been limited by sample size, disregard for temporal dynamics, and insufficient validation. We aimed to …

2021-12-01AlgemeenArtikel

Differences in mortality in critically ill elderly patients during the second COVID-19 surge in Europe

COVIP Study Group

BACKGROUND: The primary aim of this study was to assess the outcome of elderly intensive care unit (ICU) patients treated during the spring and autumn COVID-19 surges in Europe. METHODS: This was a prospective European observational study (the COVIP study) in ICU patients aged 70 years and older admitted …

2021-09-23AlgemeenArtikel

Association of intensity of ventilation with 28-day mortality in COVID-19 patients with acute respiratory failure

PRoVENT-COVID

BACKGROUND: The intensity of ventilation, reflected by driving pressure (ΔP) and mechanical power (MP), has an association with outcome in invasively ventilated patients with or without acute respiratory distress syndrome (ARDS). It is uncertain if a similar association exists in coronavirus disease …

2021-08-06AlgemeenArtikel

Sputum Proteome Signatures of Mechanically Ventilated Intensive Care Unit Patients Distinguish Samples with or without Anti-pneumococcal Activity

Seinen, Jolien; Engelke, Rudolf; Abdullah, Mohammed R; Voß, Franziska; Michalik, Stephan; Dhople, Vishnu M; Dieperink, Willem; de Smet, Anne Marie G A; Völker, Uwe; van Dijl, Jan Maarten; Schmidt, Frank; Hammerschmidt, Sven

Respiratory pathogens like Streptococcus pneumoniae can cause severe pneumonia. Nonetheless, mechanically ventilated intensive care patients, who have a high risk of contracting pneumonia, rarely develop pneumococcal pneumonia. Mechanically ventilated patients are at risk of contracting pneumonia. Therefore, …

2021-04-27AlgemeenArtikel

Ventilation and air cleaning to limit aerosol particle concentrations in a gym during the COVID-19 pandemic

Bert Blocken; Thijs van Druenen; Alessio Ricci; Luyang Kang; Twan van Hooff; Peng Qin; Lili Xia; Claudio Alanis Ruiz; Dennis Arts; Jan Diepens; G.A. Maas; Stefanie Gillmeier; Steven Vos; Aarnout Brombacher

ARS-CoV-2 can spread by close contact through large droplet spray and indirect contact via contaminated objects. There is mounting evidence that it can also be transmitted by inhalation of infected saliva aerosol particles. These particles are generated when breathing, talking, laughing, coughing or …

2021-02-04Recreatie, Beweging & SportArtikel

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