PURPOSE OF REVIEW: Protein delivery as well as exercise of critically ill in clinical practice is still a highly debated issue. Here we discuss only the most recent updates in the literature concerning protein nutrition and exercise of the critically ill. RECENT FINDINGS: By lack of randomized controlled …

From the thesis: "Summary Metabolic diseases that are characterized by a disturbance in energy balance because of feeding behavior, such as obesity and anorexia are known to be a world-wide problem. A better understanding in central regulation of energy intake and metabolism could give more insight in …

This research was created as a contribution to the internationalization strategy of RAI Amsterdam. The company wants to bring more international conferences, and exhibitions to Amsterdam. One of the objectives of this strategy is to create an ‘international standard’, which complies with the basic services, …

Probiotic bacteria harbor effector molecules that confer health benefits, but also adaptation factors that enable them to persist in the gastrointestinal tract of the consumer. To study these adaptation factors, an antibiotic-resistant derivative of the probiotic model organism Lactobacillus plantarum …

Synthetic glucocorticoids are potent anti-inflammatory drugs but show dose-dependent metabolic side effects such as the development of insulin resistance and obesity. The precise mechanisms involved in these glucocorticoid-induced side effects, and especially the participation of adipose tissue in this …

Glucocorticoids (GCs) such as prednisolone are potent immunosuppressive drugs but suffer from severe adverse effects, including the induction of insulin resistance. Therefore, development of so-called Selective Glucocorticoid Receptor Modulators (SGRM) is highly desirable. Here we describe a non-steroidal …

Basophils account for only 0.1-1% of all peripheral blood leukocytes. They were considered to be a redundant cell type for a long time. However, several findings show a non-redundant role for basophils in type 2 T-helper cell (Th2) immune responses in helminth infections, allergy and autoimmunity. Both …

BACKGROUND: Glucocorticoids (GCs) control expression of a large number of genes via binding to the GC receptor (GR). Transcription may be regulated either by binding of the GR dimer to DNA regulatory elements or by protein-protein interactions of GR monomers with other transcription factors. Although …

Het onderzoek richt zich op een inventarisatiemethode voor kleine zoogdieren, waaronder de noordse woelmuis (Microtus oeconomus). Bij het inventariseren van noordse woelmuizen wordt onder andere gebruik gemaakt van Longworth-vallen. Bij deze methode worden de vallen enkele dagen voordat ze op scherp …