As the revolutions across the Arab world that came to a head in 2011 devolved into civil war and military coup, representation and history acquired a renewed and contested urgency. The capacities of the internet have enabled sharing and archiving in an unprecedented fashion. Yet, at the same time, these …

People in western countries spend approximately 90% of their time indoors. This severely affects their health (WHO 2013; Klepeis et al. 2001). The health risks are exacerbated if people travel between indoor spaces by car or public transport. Buildings on streets specifically designed to create a human …

Wilms tumour suppressor gene (WT1) is essential for normal development of a kidney, it was also discovered as a major controller of mesenchymal-epithelial balance in general development of organs. In this project we use Wt1 and its role in the mesenchymal-epithelial balance to study the mechanism of …

Abstract 1 Scope A major downside of oral immunotherapy (OIT) for food allergy is the risk of severe side effects. Non‐digestible short‐ and long‐chain fructo‐oligosaccharides (scFOS/lcFOS) reduce allergy development in murine models. Therefore, it is hypothesized that scFOS/lcFOS can also support …

Since Factor H is the main regulator of the complement system, any dysregulation may result in either uncontrolled complement activation or inhibition. Auto-antibodies against Factor H inhibit the protective function of Factor H on host cells, which are now sensitive for complement activation. It is …

De erfelijke ziekte ADPKD (autosomaal dominant polycysteuze nierziekte) wordt gekenmerkt door het ontstaan van renale cystes. Deze cystes worden veroorzaakt door een aangeboren mutatie in het Pkd1- of Pkd2-gen (polycystic kidney disease-1 of 2 gen). Deze genen coderen voor eiwitten die bijdragen aan …

Open design appears as one in a row of similar expres - sions of ‘open X’ – open access, open data, open knowl - edge, open hardware – most of which were coined in the early years of this century and modelled after ‘open source’ in software. They denote a departure from presumably ‘closed’ practices …

Probiotic bacteria harbor effector molecules that confer health benefits, but also adaptation factors that enable them to persist in the gastrointestinal tract of the consumer. To study these adaptation factors, an antibiotic-resistant derivative of the probiotic model organism Lactobacillus plantarum …

Gedurende mijn afstudeerproject voor mijn opleiding Communicatie Multimedia & Design (CMD) aan de Haagse Hogeschool (HHS) heb ik onderzoek gedaan naar een aantal onderzoeksmethoden en op basis van een aantal te gebruiken methode een testplan geschreven. Dit testplan is vervolgens toegepast bij het uitvoeren …

BACKGROUND: Glucocorticoids (GCs) control expression of a large number of genes via binding to the GC receptor (GR). Transcription may be regulated either by binding of the GR dimer to DNA regulatory elements or by protein-protein interactions of GR monomers with other transcription factors. Although …