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Improved Efficacy of Oral Immunotherapy Using Non-Digestible Oligosaccharides in a Murine Cow's Milk Allergy Model

Marlotte M. Vonk (Onderzoeker); Mara A.P. Diks (Onderzoeker); Laura Wagenaar (Onderzoeker); J.J. Smit (Onderzoeker); Raymond Pieters (Lector); Johan Garssen (Onderzoeker); Betty C.A.M. van Esch (Onderzoeker); Léon M.J. Knippels (Onderzoeker)

From teh UU repository: "Background: Oral immunotherapy (OIT) is a promising therapeutic approach to treat food allergic patients. However, there are some concerns regarding its safety and long-term efficacy. The use of non-digestible oligosaccharides might improve OIT efficacy since they are known to …

2017GezondheidArtikel

A higher protein intake is not associated with 5-year change in mid-thigh muscle cross-sectional area by computed tomography in older adults

Verreijen, A.M.; Engberink, M.F.; Brouwer, I.A.; Cawthon, P.M.; Newman, A.B.; Tylavsky, F.A.; Harris, T.B.; Weijs, P.J.M. (Lectoraat Voeding En Beweging); Visser, M.

Rationale: A higher protein intake is suggested to preserve muscle mass during aging, and may therefore reduce the risk for sarcopenia. We explored whether the amount, type (animal/vegetable) and essential amino acid (EAA) composition of protein intake were associated with 5-year change in mid-thigh …

2017AlgemeenConferentiebijdrage

Bone mineral density is associated with muscle mass in obese older adults with diabetes type 2

Memelink, Robert G. (Lectoraat Voeding En Beweging); Verreijen, Amely M.; de Bos Kuil, Minse J.J.; Engberink, Mariëlle F.; Verlaan, Sjors; de Vogel-van den Bosch, Johan; Weijs, Peter J.M. (Lectoraat Voeding En Beweging)

Rationale: The number of obese older adults with diabetes type 2 is increasing worldwide. Weight loss treatment in this group seems beneficial for cardio-metabolic and other health outcomes, but it might reduce muscle mass and bone mineral density (BMD). The association between obesity and BMD is controversial, …

2017AlgemeenConferentiebijdrage

Protein intake and clinical and functional outcome in ICU patients

Guadagni, M.; Streppel, M.T. (Lectoraat Voeding En Beweging); Schuurman, C.; Biolo, G.; Boirie, Y.; Rooijackers, O.; Kondrup, J.; Weijs, P.J.M. (Lectoraat Voeding En Beweging)

2017AlgemeenConferentiebijdrage

Protein turnover and metabolism in the elderly intensive care unit patient

Phillips, Stuart M.; Dickerson, Roland N.; Moore, Frederick A.; Paddon-Jones, Douglas; Weijs, Peter J. M. (Lectoraat Voeding En Beweging)

Many intensive care unit (ICU) patients do not achieve target protein intakes particularly in the early days following admittance. This period of iatrogenic protein undernutrition contributes to a rapid loss of lean, in particular muscle, mass in the ICU. The loss of muscle in older (aged >60 years) …

2017AlgemeenArtikel

Effect of a high protein diet and/or resistance exercise on the preservation of fat free mass during weight loss in overweight and obese older adults: a randomized controlled trial

Verreijen, Amely M; Engberink, Mariëlle F; Memelink, Robert G (Lectoraat Voeding En Beweging); van der Plas, Suzanne E (Faculteit Bewegen, Sport En Voeding); Visser, Marjolein; Weijs, Peter J M (Lectoraat Voeding En Beweging)

BACKGROUND: Intentional weight loss in obese older adults is a risk factor for accelerated muscle mass loss. We investigated whether a high protein diet and/or resistance exercise preserves fat free mass (FFM) during weight loss in overweight and obese older adults. METHODS: We included 100 overweight …

2017AlgemeenArtikel

Validatie van een LC-MS/MS methode voor Tariquidar, Elacridar en een mengsel van substraten voor P-gp en Bcrp1 en toepassing voor in vivo farmacokinetiek studies

Nikkie Venekamp (Student)

Het NKI is een oncologisch onderzoekscentrum waar wetenschappelijk onderzoek gedaan wordt naar verschillende soorten kanker. Op de afdeling Bio-Farmacologie wordt er voornamelijk onderzoek gedaan naar geneesmiddelen, of een combinatie ervan, die hersentumoren bestrijden. Er worden in vitro en in vivo …

2016-11-25TechniekBachelor

Protein intake, nutritional status and outcomes in ICU survivors

Weijs, P.J.M. (Lectoraat Voeding En Beweging); Mogensen, K.M.; Rawn, J.D.; Robinson, M.K.; Christopher, K.B.

2016-09AlgemeenArtikel

Protein delivery in critical illness

Weijs, Peter J.M. (Lectoraat Voeding En Beweging)

PURPOSE OF REVIEW: Protein delivery in the critically ill still is a highly debated issue. Here, we discuss only the most recent updates in the literature concerning protein nutrition of the critically ill. RECENT FINDINGS: Up to now, there are no randomized controlled trials (RCTs) published on enteral …

2016-08AlgemeenArtikel

Human variome project quality assessment criteria for variation databases

Mauno Vihinen (Onderzoeker); John M. Hancock (Onderzoeker); Donna R. Maglott (Onderzoeker); Melissa J. Landrum (Onderzoeker); Gerard C. P. Schaafsma (Onderzoeker); Peter Taschner (Lector)

Numerous databases containing information about DNA, RNA, and protein variations are available. Gene‐specific variant databases (locus‐specific variation databases, LSDBs) are typically curated and maintained for single genes or groups of genes for a certain disease(s). These databases are widely considered …

2016-04-26GezondheidArtikel

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