Alzheimer's disease is a complex neurodegenerative disease and the most prevalent form of dementia. It affects every 14th person after the age of 65, thus making it a serious concern in modern society. Furthermore, currently available treatment is restricted only to symptomatic and is not highly effective. …

Doel: Het doel is om op systematische wijze bestaande informatie te verkrijgen en te kunnen verstrekken over de zin van EMDR bij tandartsangst en het klinische bewijs hiervoor. De korte en lange termijn effecten van EMDR op tandartsangst worden onderzocht. Aan de hand van de vernieuwde informatie kan …

Alzheimer's disease (AD) is the common neurodegenerative disorder and the most frequent cause of dementia. The disease accounts around 80% of all dementia diagnoses. The main reason of developing AD is amyloid cascade which starts from missense mutations in APP (amyloid precursor protein), Rho-associated …

Sepsis is a life-threatening organ dysfunction caused by a dysregulated immune response to infection. It is the number one cause of death in the Intensive Care Unit (ICU), accounting for 6 million casualties every year. Unfortunately, all clinical trials in the last decade failed due to the highly complex …

Balance deficits play a major role in patients who have suffered strokes. It is estimated that 30% of patients cannot walk independently 6 months post-stroke, usually caused by impaired standing balance due to hemiplegia or hemiparesis that is experienced. Balance as a whole is a key factor when it comes …

Dwarslaesiepatiënten kunnen door de gevolgen van de laesie, zoals verlamming en verlies van sensorische input, verminderde rompstabiliteit hebben. Rompstabiliteit is het behouden, bereiken of herstellen van de balans. Het hebben van een adequate rompstabiliteit is belangrijk voor het vergroten van de …

Voluntary breath-hold is the mostly used method using 8 breath-holds of 25 seconds. The respondents do recognize the benefits of using 60%O2, but they are not sure about using it in clinical practice. The percentage of patients who cannot hold their breath for the required duration is 5%, with the …

Evidence-based practice (EBP) is the integration of the current best evidence, with clinical expertise and patient values in the decision making about the care of individual patients. This concept has been widely adopted by the profession of physiotherapy. The application and practice of EBP by physiotherapists …

SMPD4 is a neutral sphingomyelinase that plays an important role in sphingolipid metabolism. Sphingolipids are a family of lipid molecules abundantly present in the brain where they play an important role in the brain development and function due to their essential cellular role as structural components …

Cancer was diagnosed in 19.292.789 patients worldwide in 2020, depending on the type of cancer treatment may involve chemotherapy. If a neurotoxic agent is used, patients can develop chemotherapy-induced peripheral neuropathy (CIPN) affecting 68% of patients within the first months of treatment. CIPN …