Ubiquitin (Ub) is a protein which post-translationally modifies other proteins (its target substrates) and determines their cellular fate. Ub can label substrates for degradation, it can also alter the location of their substrates within a cell or even affect their activity. Chains can be formed via …

There is increased interest in reducing sedentary behavior of office workers to combat the negative health effects of prolonged sitting. Walking meetings offer a promising solution to this problem as they facilitate a physically active way of working. To inform future development of technologies supporting …

Klotho knock-out mice are an important model for vascular calcification, which is associated with chronic kidney disease. In chronic kidney disease, serum magnesium inversely correlates with vascular calcification. Here we determine the effects of serum magnesium on aortic calcification in Klotho knock-out …

Although dozens of empirical studies have been published on effectuation as a whole, much work remains to be done on elaborating each principle in more depth. Based on an exploratory study of seven ventures from the Caribbean island of Curacao, this paper develops an elaborated process model of the affordable …

The following research aims to determine the factors that influence the degree of the participation of women in the military in NATO member states. Segal’s theoretical model was chosen to determine the factors as it, unlike other theories that explain women’s participation in the military, provides an …

Introduction International placements challenge students to find the right level of participation, as local practices, language and time pressure may affect their engagement in patient-related tasks or team activities. This study sought to unpack the initiation process during international clinical placements …

Background: Twinning collaborations, where two groups — from educational institutions, hospitals or towns — work together cross-culturally on joint goals, are increasingly common worldwide. Pairing up individuals, so-called twin pairs, is thought to contribute to successful collaboration in twinning …

During incubation, an embryo is developing in the egg for a period of 21 days. During the incubation process air exchange occurs between the egg and its external environment during which it loses humidity due to water diffusion through the shell. This loss in humidity can affect chicks’ quality and, …

Banks in the Netherlands are involved in Corpore Social Responsibility (CSR). What banks do for Corporate Social Responsibility and how they do it is not always clear. Different motives for Corporate Social Responsibility exist and as an effect, it remains questionable how customers would react to CSR …

The purpose of this article is to explore innovative and adaptive ways of matching people with jobs in the context of a Dutch policy initiative aimed at the skills mismatch in the region of Amsterdam. This is an important and urgent issue because of the challenges of the future labor market, in which …