Cardiovascular diseases (CVDs) are by far the leading cause of death due to non communicable diseases in the world. The development of CVDs in many cases is caused by atherosclerosis. In atherosclerosis, plaques in blood vessels are formed by the excessive accumulation of lipids in the endothelial lining. …

Cardiovasculaire aandoeningen zijn wereldwijd de meest voorkomende doodsoorzaak en zorgen voor aanzienlijke zorgkosten. Het risico op deze aandoeningen neemt toe met de leeftijd, waarbij de oudere populatie aanzienlijk bijdraagt aan de totale zorgkosten. De AGE Reader mu, een innovatief apparaat dat …

Diabetes remains a major risk for atherosclerotic-cardiovascular disease (CVD). While many mechanisms have been explored, the full extent of how diabetes promotes CVD remains unknown. An emerging area in diabetes is the influence of epigenetic regulation of gene expression. Diabetes has been shown to …

Sodium-glucose co-transporter 2 (SGLT2) inhibitors, including canagliflozin, reduce the risk of cardiovascular and kidney outcomes in patients with and without type 2 diabetes, albeit with a large interindividual variation. The underlying mechanisms for this variation in response might be attributed …

Background A high sedentary time is associated with increased mortality risk. Previous studies indicate that replacement of sedentary time with light- and moderate-to-vigorous physical activity attenuates the risk for adverse outcomes and improves cardiovascular risk factors. Patients with cardiovascular …

BACKGROUND: The reliability and validity of the subjective component of the Dutch Objective Burden Inventory (DOBI) are unknown. OBJECTIVE: The validity and reliability of the subjective component of the DOBI were examined in caregivers of individuals with heart failure, using the original 38- and a …

Smoking among people with severe mental illness (SMI) is highly prevalent and strongly associated with poor physical health. Currently, evidence-based smoking cessation interventions are scarce and need to be integrated into current mental health care treatment guidelines and clinical practice. Therefore, …

Objectives: Health problems in patients with heritable connective tissue disorders (HCTD) are diverse and complex and might lead to lower physical activity (PA) and physical fitness (PF). This study aimed to investigate the PA and PF of children with heritable connective tissue disorders (HCTD). Methods: …

It is suggested that older patients waiting for an elective surgical procedure have a poor nutritional status and low physical activity level. It is unknown if this hypothesis is true and if these conditions improve after a medical procedure. We aimed to determine the trajectory of both conditions before …

Objectives To identify factors associated with kinesiophobia (fear of movement) after cardiac hospitalisation and to assess the impact of kinesiophobia on cardiac rehabilitation (CR) initiation. Design Prospective cohort study. Setting Academic Medical Centre, Department of Cardiology. Participants We …