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Long-term swallowing, trismus, and speech outcomes after combined chemoradiotherapy and preventive rehabilitation for head and neck cancer; 10-year plus update

Karsten, Rebecca T.; van der Molen, Lisette; Hamming-Vrieze, Olga; van Son, RobJ. J. J. H.; Hilgers, Frans J. M.; van den Brekel, Michiel W. M.; Stuiver, Martijn M (Urban Vitality); Smeele, Ludi E.

BACKGROUND: The objective of this study was to explore the 10-year plus outcomes of Intensity Modulated Radiotherapy with concomitant chemotherapy (CRT) combined with preventive swallowing rehabilitation (CRT+) for head and neck cancer (HNC). METHODS: Subjective and objective swallowing, trismus, and …

2020AlgemeenArtikel

Continuous versus intermittent infusion of cefotaxime in critically ill patients

Aardema, Heleen; Bult, Wouter; van Hateren, Kai; Dieperink, Willem; Touw, Daan J; Alffenaar, Jan-Willem C; Zijlstra, Jan G; Dieperink, Willem

BACKGROUND: In critical care patients, reaching optimal β-lactam concentrations poses challenges, as infections are caused more often by microorganisms associated with higher MICs, and critically ill patients typically have an unpredictable pharmacokinetic/pharmacodynamic profile. Conventional intermittent …

2019-11-07AlgemeenArtikel

Effect of physical exercise on cognitive function and brain measures after chemotherapy in patients with breast cancer (PAM study): protocol of a randomised controlled trial

Witlox, Lenja; Schagen, Sanne B; de Ruiter, Michiel B; Geerlings, Mirjam I; Peeters, Petra H M; Koevoets, Emmie W; van der Wall, Elsken; Stuiver, Martijn (Faculteit Gezondheid); Sonke, Gabe; Velthuis, Miranda J; Palen, Job A M van der; Jobsen, Jan J; May, Anne M; Monninkhof, E M

INTRODUCTION: After treatment with chemotherapy, many patients with breast cancer experience cognitive problems. While limited interventions are available to improve cognitive functioning, physical exercise showed positive effects in healthy older adults and people with mild cognitive impairment. The …

2019-06AlgemeenArtikel

Long-Term Tumor-Free Survival in a Patient with Stage IV Epithelial Ovarian Cancer Undergoing High-Dose Chemotherapy and Viscum album Extract Treatment: A Case Report

Paul G. Werthmann (Onderzoeker); Robert Kempenich (Onderzoeker); Gunver S. Kienle (Onderzoeker)

Epithelial ovarian cancer (EOC) has a poor prognosis in advanced stages. High-dose chemotherapy (HDC) was pursued in the 1990s but was not found to improve survival of patients with EOC in larger studies. Many patients with cancer use Viscum album extracts (VAE). Also called European mistletoe, Viscum …

2019-02-18GezondheidArtikel

Long-term tumor-free survival in a metastatic pancreatic carcinoma patient with FOLFIRINOX/Mitomycin, high-dose, fever inducing Viscum album extracts and subsequent R0 resection

Paul G. Werthmann (Onderzoeker); Pia Inter (Onderzoeker); Thilo Welsch (Onderzoeker)

Rationale: Metastatic pancreatic cancer has a dismal prognosis. Many patients seek integrative care as an add-on to their conventional cancer treatment. Viscum album extracts (VAE)—widely used as an adjunct to cancer treatment—have cytotoxic, apoptogenic, and immune stimulatory properties. A statistically …

2018-10-22GezondheidArtikel

Complete remission and long-term survival of a patient with a diffuse large B-cell lymphoma under Viscum album extracts after resistance to R-CHOP

Erik Baars (Lector); Johannes Gutsch (Onderzoeker); Paul G. Werthmann (Onderzoeker); Andreas Rosenwald (Onderzoeker); Gunver S. Kienle (Onderzoeker)

Background: A nodular lymphocyte predominant Hodgkin's lymphoma (NLPHL) is a lymphoproliferative neoplasm with a fair prognosis, but the possibility of a malignant transformation into a diffuse large B-cell lymphoma (DLBCL) is high. DLBCL progresses aggressively. Introduction of rituximab into therapy …

2018-07-24GezondheidArtikel

A 21-year course of Merkel cell carcinoma with adjuvant Viscum album extract treatment

Paul G. Werthmann (Onderzoeker); Lothar Kindermann (Onderzoeker); Gunver S. Kienle (Onderzoeker)

Background Merkel cell carcinoma (MCC) is a rare, aggressive, neuroendocrine skin tumor with frequent local recurrence, lymph node involvement, distant metastasis, and a high mortality rate. Viscum album extracts (VAE) are a widely used adjunct in cancer treatment and show cytotoxic and immune-modulating …

2018-04-09GezondheidArtikel

Durable clinical remission of a skull metastasis under intralesional Viscum album extract therapy

Paul G. Werthmann (Onderzoeker); Roman Huber (Onderzoeker); Gunver S. Kienle (Onderzoeker)

Background Skull metastases are rare, they can eventually cause pain, and can invade the brain. Viscum album extracts (VAEs) are used as an adjuvant treatment in cancer. Methods and Results A 68‐year‐old patient with rectal cancer presented with lung metastases, and metastases to multiple bone sites, …

2018GezondheidArtikel

Developing a patient decision aid for the treatment of women with early stage breast cancer

W. Savelberg; T. van der Weijden; L. Boersma; M. Smidt; C. Willekens; Albine Moser

Background: A patient decision aid (PtDA) can support shared decision making (SDM) in preference-sensitive care, with more than one clinically applicable treatment option. The development of a PtDA is a complex process, involving several steps, such as designing, developing and testing the draft with …

2017-08-01GezondheidArtikel

Clozapine re-exposure after dilated cardiomyopathy

Mariëtte Nederlof (Onderzoeker); Theo WJ Benschop (Onderzoeker); Cornelia Adriana de Vries Feyens (Onderzoeker); Rob Heerdink (Lector)

from the publishers' website: "A 63-year-old woman with diabetes type II and a history of breast cancer was treated with clozapine for her refractory schizophrenia. She developed a dilated cardiomyopathy with an ejection fraction of 25%, a life-threatening event. The cause of heart failure could be multifactorial, …

2017-05-27GezondheidArtikel

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