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Effects of EU harmonization policies on national public supervision of clinical trials

Jacqueline van Oijen (Onderzoeker); Hester van de Bovenkamp (Onderzoeker); Roland Bal (Onderzoeker); Kor Grit (Onderzoeker)

This paper analyzes how endeavours to implement the EUCTD set in motion a dynamic process of institutional change and institutional work. This process lead to substantial differences between policy and actual practice; therefore, it is important to learn more about the implementation of harmonization policies …

2017-09-21GezondheidArtikel

Protein nutrition and exercise survival kit for critically ill

Weijs, Peter J.M. (Lectoraat Voeding En Beweging)

PURPOSE OF REVIEW: Protein delivery as well as exercise of critically ill in clinical practice is still a highly debated issue. Here we discuss only the most recent updates in the literature concerning protein nutrition and exercise of the critically ill. RECENT FINDINGS: By lack of randomized controlled …

2017-08-01AlgemeenArtikel

Whole medical systems versus the system of conventional biomedicine

Erik Baars (Lector); Harald J. Hamre (Onderzoeker)

Background. There is an increasing need for a worldwide professional integration of conventional medicine and traditional/complementary whole medical systems (WMSs). However, the integration is perceived by conventional medicine as problematic or unacceptable, because of a supposed lack of evidence for …

2017-07-13GezondheidArtikel

Summary points and consensus recommendations from the international protein summit

Hurt, Ryan T; McClave, Stephen A; Martindale, Robert G; Ochoa Gautier, Juan B; Coss-Bu, Jorge A; Dickerson, Roland N; Heyland, Daren K; Hoffer, L John; Moore, Frederick A; Morris, Claudia R; Paddon-Jones, Douglas; Patel, Jayshil J; Phillips, Stuart M; Rugeles, Saúl J; Sarav Md, Menaka; Weijs, Peter J M (Lectoraat Voeding En Beweging); Wernerman, Jan; Hamilton-Reeves, Jill; McClain, Craig J; Taylor, Beth

The International Protein Summit in 2016 brought experts in clinical nutrition and protein metabolism together from around the globe to determine the impact of high-dose protein administration on clinical outcomes and address barriers to its delivery in the critically ill patient. It has been suggested …

2017-04-07AlgemeenArtikel

Body image in patients with mental disorders: characteristics, associations with diagnosis and treatment outcome

Mia Scheffers; Jooske van Busschbach; Ruud J. Bosscher; Liza C. Aerts; Durk Wiersma; R.A. Schoevers

Objective Despite the increasing recognition in clinical practice of body image problems in other than appearance related mental disorders, the question remains how aspects of body image are affected in different disorders. The aim of this study was to measure body image in patients with a variety of …

2017-04GezondheidArtikel

Recommended Guidelines for Validation, Quality Control, and Reporting of TP53 Variants in Clinical Practice

Bernard Leroy (Onderzoeker); Mandy L. Ballinger (Onderzoeker); Fanny Baran-Marszak (Onderzoeker); Peter Taschner (Lector)

Accurate assessment of TP53 gene status in sporadic tumors and in the germline of individuals at high risk of cancer due to Li–Fraumeni Syndrome (LFS) has important clinical implications for diagnosis, surveillance, and therapy. Genomic data from more than 20,000 cancer genomes provide a wealth of information …

2017-03-14GezondheidArtikel

Criteria in diagnosing nocturnal leg cramps

Hallegraeff, Joannes; de Greef, Mathieu; Krijnen, Wim (Statistical Techniques For Applied Research); van der Schans, Cees

BACKGROUND: Up to 33% of the general population over 50 years of age are affected by nocturnal leg cramps. Currently there are no generally accepted clinical characteristics, which identify nocturnal leg cramps. This study aims to identify these clinical characteristics and to differentiate between them …

2017-02-28Gezondheid; …Andersoortig materiaal

Clinical practice: evidence-based recommendations for the treatment of Cervical Dystonia with Botulinum Toxin

Contarino, Maria Fiorella; Van den Dool, Joost; Balash, Yacov; Bhatia, Kailash; Giladi, Nir; Koelman, Johannes H.; Lokkegaard, Annemette; Marti, Maria J.; Postma, Miranda; Relja, Maja; Skorvanek, Matej; Speelman, Johannes D.; Zoons, Evelien; Ferreira, Joaquim J.; Vidailhet, Marie; Albanese, Alberto; Tijssen, Marina A. J.

Cervical dystonia is the most frequent form of focal dystonia. Symptoms often result in pain and functional disability. Local injections of botulinum neurotoxin are currently the treatment of choice for cervical dystonia. Although this treatment has proven effective and is widely applied worldwide, many …

2017-02-24AlgemeenArtikel

Study protocol for a randomised controlled multicentre study

Broekema, A.E. (.) (Researcher); Kuilen, J.M. (.) (Researcher); Lesman-Leegte, G.A. (.) (Researcher); Bartels, R.H. (.) (Researcher); Asselt, A.D. (.) van (Researcher); Vroomen, P.C. (.) (Researcher); Dijk, J.M. (.) van (Researcher); Reneman, M.F. (.) (Researcher); Soer, R. (Remco) (Associatelector); Groen, R.J. (.) (Researcher)

The Foraminotomy ACDF Cost-Effectiveness Trial (FACET) study is the first randomised controlled trial investigating anterior discectomy with fusion versus foraminotomy for cervical foraminal pathology. Methodological strengths include an appropriate sample size based on a non-inferiority design, seven …

2017-01-01AlgemeenArtikel

A new clinical test for measurement of lower limb specific range of motion in football players

Tak, I J R; Langhout, R F H; Groters, S; Weir, A; Stubbe, J H; Kerkhoffs, G M M J

OBJECTIVE: The association between groin pain and range of motion is poorly understood. The aim of this study was to develop a test to measure sport specific range of motion (SSROM) of the lower limb, to evaluate its reliability and describe findings in non-injured (NI) and injured football players. …

2017-01AlgemeenArtikel

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