Mammalian promoters can be separated into two classes, conserved TATA box-enriched promoters, which initiate at a well-defined site, and more plastic, broad and evolvable CpG-rich promoters. We have sequenced tags corresponding to several hundred thousand transcription start sites (TSSs) in the mouse …

Seven new 1,3,5-cyclohexyltricarboxamide-phenylalanine derivatives were synthesized in order to investigate the effect of the amino acid chirality on the gelating properties of these small molecules in water. Gelation tests have shown that enantiomerically pure homochiral 1,3,5-cyclohexyltricarboxamide-L-phenylalanine …

INTRODUCTION: A stay in the intensive care unit (ICU), although potentially life-saving, may cause considerable discomfort to patients. However, retrospective assessment of discomfort is difficult because recollection of stressful events may be impaired by sedation and severe illness during the ICU stay. …

A great deal of research has been undertaken to identify the factors affecting the success, failure, performance and stability of international equity joint ventures (EJVs) (see, for example, Beamish and Killing, 1996 for a review). Most of these studies, however, are static in nature. Although some …

Het gezichtspunt dat ik in deze bijdrage zal betrekken is dat de ecologische crisis zich niet alleen in onze omgeving – ons milieu – afspeelt, maar voor een belangrijk deel ook in onze persoon. Veel westerse mensen voelen nu een onbestemd gevoel van onthechting, van geestelijke eenzaamheid. Hoe nog een …