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The impact of gastrointestinal and genitourinary toxicity on health related quality of life among irradiated prostate cancer patients

Schaake, Wouter (Healthy Ageing, Allied Health Care And Nursing); Wiegman, Erwin M.; de Groot, Martijn; van der Laan, Hans Paul; van der Schans, Cees; van den Bergh, Alfons C.M.; Langendijk, Johannes A.

PURPOSE: To determine the impact of late radiation-induced toxicity on health-related quality of life (HRQoL) among patients with prostate cancer. PATIENTS AND METHODS: The study sample was composed of 227 patients, treated with external beam radiotherapy. Common Terminology Criteria for Adverse Events …

2014-02-01AlgemeenArtikel

TTIP: EU GMO policy alignment?

Isabella Stojkovski (Student); Paul Shotton (Begeleider)

De onderhandelingen tussen de EU en de VS (Transatlantic Trade and Investment Partnership - TTIP) begonnen in 2013. Ze hebben als doel het slechten van handelsbarrières en het harmoniseren en standaardiseren van voorschriften. In de thesis wordt onderzocht, in hoeverre de regelgeving in de EU op het …

2014Economie & Management; …Bachelor

Prednisolone induces the Wnt signalling pathway in 3T3-L1 adipocytes

Fleuren, Wilco W M; Linssen, Margot M L; Toonen, Erik J M; van der Zon, Gerard C M; Guigas, Bruno; de Vlieg, Jacob; Dokter, Wim H A; Ouwens, D Margriet; Alkema, Wynand

Synthetic glucocorticoids are potent anti-inflammatory drugs but show dose-dependent metabolic side effects such as the development of insulin resistance and obesity. The precise mechanisms involved in these glucocorticoid-induced side effects, and especially the participation of adipose tissue in this …

2013-03-19AlgemeenArtikel

Natura 2000 op de Brabantse Wal : kans of knelpunt?

Paul, K.J. (Student); Konings, M.C.E.; Rosier, T.B.G.M.

Een onderzoek naar de gevolgen van Natura 2000 voor particuliere grondbezitters op de Brabantse Wal. Dit gebied is in 2013 aangewezen als Natura 2000 gebied. De provincie kwam aansluitend met een beheerplan voor het 4790 ha grote gebied. Nu willen de grondeigenaren inzicht verkrijgen voor de mogelijke …

2013Natuur & LandbouwBachelor

Org 214007-0

van Lierop, Marie-José C; Alkema, Wynand; Laskewitz, Anke J; Dijkema, Rein; van der Maaden, Hans M; Smit, Martin J; Plate, Ralf; Conti, Paolo G M; Jans, Christan G J M; Timmers, C Marco; van Boeckel, Constant A A; Lusher, Scott J; McGuire, Ross; van Schaik, Rene C; de Vlieg, Jacob; Smeets, Ruben L; Hofstra, Claudia L; Boots, Annemieke M H; van Duin, Marcel; Ingelse, Benno A; Schoonen, Willem G E J; Grefhorst, Aldo; van Dijk, Theo H; Kuipers, Folkert; Dokter, Wim H A

Glucocorticoids (GCs) such as prednisolone are potent immunosuppressive drugs but suffer from severe adverse effects, including the induction of insulin resistance. Therefore, development of so-called Selective Glucocorticoid Receptor Modulators (SGRM) is highly desirable. Here we describe a non-steroidal …

2012-11-12AlgemeenArtikel

The perspective of forest regeneration with new wildlife migration possibilities : a research performed in “Het Nationale Park De Hoge Veluwe” on the effects on forest regeneration when free migration of ungulates is possible after putting two wildlife crossings into use

Kuipers, B. (Student); Wanrooij, F. van (Student); Breeje, L. den (Student); onbekend

As part of the “Ecological main structure” the province of Gelderland strives to make the migration for ungulates possible on the Veluwe. Two wildlife crossings have been build, but are not yet operational because the fence around the National Park Hoge Veluwe is still in place. The fence will be lowered …

2012Natuur & LandbouwBachelor

Prednisolone-induced beta cell dysfunction is associated with impaired endoplasmic reticulum homeostasis in INS-1E cells

Linssen, Margot M L; van Raalte, Daniel H; Toonen, Erik J M; Alkema, Wynand; van der Zon, Gerard C; Dokter, Wim H; Diamant, Michaela; Guigas, Bruno; Ouwens, D Margriet

Glucocorticoids (GCs), such as prednisolone (PRED), are widely prescribed anti-inflammatory drugs, but their use may induce glucose intolerance and diabetes. GC-induced beta cell dysfunction contributes to these diabetogenic effects through mechanisms that remain to be elucidated. In this study, we hypothesized …

2011-11-01AlgemeenArtikel

Prednisolone-induced changes in gene-expression profiles in healthy volunteers

Toonen, Erik J M; Fleuren, Wilco W M; Nässander, Ulla; van Lierop, Marie-José C; Bauerschmidt, Susanne; Dokter, Wim H A; Alkema, Wynand

BACKGROUND: Prednisolone and other glucocorticoids (GCs) are potent anti-inflammatory and immunosuppressive drugs. However, prolonged use at a medium or high dose is hampered by side effects of which the metabolic side effects are most evident. Relatively little is known about their effect on gene-expression …

2011-07-25AlgemeenArtikel

Hyperbaric Oxygen Therapy: Solution for Difficult to Heal Acute Wounds? Systematic Review

Eskes, Anne M. (Faculteit Gezondheid); Ubbink, Dirk T.; Lubbers, Maarten J.; Lucas, Cees; Vermeulen, Hester

Background Hyperbaric oxygen therapy (HBOT) is used to treat various wound types. However, the possible beneficial and harmful effects of HBOT for acute wounds are unclear. Methods We undertook a systematic review to evaluate the effectiveness of HBOT compared to other interventions on wound healing …

2011-03AlgemeenArtikel

The effect of work pace on workload, motor variability and fatigue during simulated light assembly work

Bosch, T.; Mathiassen, S.E.; Visser, B. (Lectoraat Oefentherapie); de Looze, M.P.; van Dieën, J.H.

This study investigated the effect of work pace on workload, motor variability and fatigue during light assembly work. Upper extremity kinematics and electromyography (EMG) were obtained on a cycle-to-cycle basis for eight participants during two conditions, corresponding to "normal" and "high" work …

2011-02AlgemeenArtikel

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