Background The ROS1 G2032R mutation is the most common on-target resistance mutation in crizotinib treated ROS1-positive lung cancer patients. The aim of our study was to investigate resistance mechanisms in SCL34A2-ROS1G2032R positive Ba/F3 cells against second line treatment with lorlatinib. Methods …

Aggregation into groups may affect performance of individuals through the balance and strength of facilitative versus competitive interactions. We studied in situ how seasonal variation in abiotic environment affects this balance for blue mussels, a semi-sessile species. We hypothesize that seasonal …

Dat onze energietoekomst onzeker is, zal iedereen beamen. In feite vormt de energietransitie één groot experiment. De auteurs van het concept Nationaal Plan Energie (NPE) stellen volgens hem dan ook terecht dat het “toekomstbeeld inherent onzeker is en afhankelijk van tal van aannames.” We weten domweg …

This paper addresses an approach to teaching embedded systems programming through a challenge-based competition involving robots. This pedagogical project distinguishes itself by incorporating international students from three international institutions through the Blended Intensive Program (BIP). The …

Background: Despite the availability of a wide variety of evidence-based treatments for major depressive disorder (MDD), many patients still experience impairments in their lives after remission. Programs are needed that effectively support patients in coping with these impairments. The program Storytelling …

Gastcollege, De Haagse Hogeschool 6 okt 2023 1. Inleiding Nature-based solutions. NBS is een concept dat naar voren is gekomen als een goed alternatief voor of aanvulling op traditionele grijze technische oplossingen. NBS maken gebruik van natuurlijke processen en ecosysteemdiensten voor functionele …

De nieuwe herindelingsgemeente Midden-Groningen wil leefbaarheids- en welzijnsproblemen binnen dorpen, buurten en wijken stevig aanpakken. Vergeleken met elders in Nederland heerst er onder de inwoners van de gemeente gemiddeld meer armoede en werkloosheid en is er sprake van een lagere levensverwachting …

Background For families with adolescent children, the transition to adulthood is usually challenging. This period may be extra demanding for families with a child with profound intellectual and multiple disabilities due to the child's strong and persistent support needs. To support these families during …

Densely populated areas are major sources of air, soil and water pollution. Agriculture, manufacturing, consumer households and road traffic all have their share. This is particularly true for the country featured in this paper: the Netherlands. Continuous pollution of the air and soil manifests itself …