Evaluating protein kinetics in the critically ill population remains a very difficult task. Heterogeneity in the intensive care unit (ICU) population and wide spectrum of disease processes creates complexity in assessing protein kinetics. Traditionally, protein has been delivered in the context of total …

From the thesis: "Summary Metabolic diseases that are characterized by a disturbance in energy balance because of feeding behavior, such as obesity and anorexia are known to be a world-wide problem. A better understanding in central regulation of energy intake and metabolism could give more insight in …

The primary aims of this study were (1) to evaluate whole-body mechanical efficiency (ME) in a large group of chronic obstructive pulmonary disease (COPD) patients with a wide range of degrees of illness and (2) to examine how ME in COPD is related to absolute work rate and indices of disease severity …

BACKGROUND & AIMS: Lower birth weight is associated with an increased risk of cardiovascular and metabolic disease. These associations may, at least in part, be explained by alterations in dietary intake in later life. The aim of this study is to examine whether lower birth weight is associated with …

Rationale: The number of obese older adults with diabetes type 2 is increasing worldwide. Weight loss treatment in this group seems beneficial for cardio-metabolic and other health outcomes, but it might reduce muscle mass and bone mineral density (BMD). The association between obesity and BMD is controversial, …

BACKGROUND: Over 30 % of older patients experience hospitalization-associated disability (HAD) (i.e., loss of independence in Activities of Daily Living (ADLs)) after an acute hospitalization. Despite its high prevalence, the mechanisms that underlie HAD remain elusive. This paper describes the protocol …

Combined lifestyle interventions (CLIs) are designed to reduce risk factors for lifestyle-related diseases through increasing physical activity and improvement of dietary behaviour. Objective. To evaluate the effects of a CLI for overweight and obese patients on lifestyle-related risk factors and …

Maintaining energy balance is a challenge shared by all animals which has resulted in an enormous variety of strategies for maintaining this vital balance. One of these is torpor, a mechanism that slows down basic metabolic rate (BMR) which results in a low expenditure of energy otherwise used to maintain …

Inleiding: Bij de Nutritional Assessment Faciliteit (NAF) van de Haagse Hogeschool (HHS) worden allerlei metingen van het rustmetabolisme (RMR=Resting Metabolic Rate) uitgevoerd. Voor metingen van de RMR heeft de NAF in begin 2016 een nieuwe indirecte calorimeter aangeschaft, de COSMED Quark RMR. De …