Several models in data analysis are estimated by minimizing the objective function defined as the residual sum of squares between the model and the data. A necessary and sufficient condition for the existence of a least squares estimator is that the objective function attains its infimum at a unique …

De behoefte om informatie te ordenen zodat ze 'beheersbaar' wordt, resulteert vaak in een top-down aanpak zoals bibliotheeksystemen die kennen. Betrekkelijk nieuw is de bottom-up aanpak, metadatering gebaseerd op het sociale aspect van consensus. Sybilla Poortman en Gerard Bierens zoomen in op de achtergronden …

The analysis of regulatory regions in genome sequences is strongly based on the detection of potential transcription factor binding sites. The preferred models for representation of transcription factor binding specificity have been termed position-specific scoring matrices. JASPAR is an open-access …