BACKGROUND: Advantages of outpatient exercise training are reduced waiting lists, better compliance, reduced time investment by the patient with reduced travel expenses, and less dependence on other people to participate. Therefore, this systematic review studies the effects of outpatient exercise training …

Glucocorticoids (GCs), such as prednisolone (PRED), are widely prescribed anti-inflammatory drugs, but their use may induce glucose intolerance and diabetes. GC-induced beta cell dysfunction contributes to these diabetogenic effects through mechanisms that remain to be elucidated. In this study, we hypothesized …

BACKGROUND: Prednisolone and other glucocorticoids (GCs) are potent anti-inflammatory and immunosuppressive drugs. However, prolonged use at a medium or high dose is hampered by side effects of which the metabolic side effects are most evident. Relatively little is known about their effect on gene-expression …

Background Hyperbaric oxygen therapy (HBOT) is used to treat various wound types. However, the possible beneficial and harmful effects of HBOT for acute wounds are unclear. Methods We undertook a systematic review to evaluate the effectiveness of HBOT compared to other interventions on wound healing …

This study investigated the effect of work pace on workload, motor variability and fatigue during light assembly work. Upper extremity kinematics and electromyography (EMG) were obtained on a cycle-to-cycle basis for eight participants during two conditions, corresponding to "normal" and "high" work …

To reduce unintentional and avoidable adverse events in patients in hospitals in the Netherlands, a patient safety agency (VMS) programme was launched in 2008. Among the VMS topics, the programme optimal therapy in severe sepsis, according to the international Surviving Sepsis Campaign (SSC), aims to …

In Zuid-kennemerland ligt een groot aantal duinpoelen. Het gebied wordt integraal begraasd door Schotse Hooglanders, Shetlandpony’s en Konikpaarden, om vergrassing en verstruweling tegen te gaan en gevarieerde vegetatiestructuren te bevorderen. De duinpoelen vormen voor deze dieren graas- en drinkgelegenheden. …

In het Nationaal Park zijn verschillende gebieden aangewezen waar voor verstoringsgevoelige soorten rust en ruimte moeten kunnen vinden om duurzame populaties te ontwikkelen. Twee van deze gebieden worden in dit onderzoek behandeld: het Leersumse Veld en de Amerongse Berg. Van deze gebieden wordt in …

Introduction: To reduce continuously increasing costs in drug development, adverse effects of drugs need to be detected as early as possible in the process. In recent years, compound-induced gene expression profiling methodologies have been developed to assess compound toxicity, including Gene Ontology …