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Study protocol of a prospective multicenter study comparing (cost-)effectiveness of a tailored interdisciplinary head and neck rehabilitation program to usual supportive care for patients treated with concomitant chemo- or bioradiotherapy

Beck, Ann-Jean C C; Passchier, Ellen; Retèl, Valesca P; Stuiver, Martijn M (Urban Vitality); van der Molen, Lisette; Klop, Willem M C; Navran, Arash; van Harten, Wim H; van den Brekel, Michiel W M

BACKGROUND: Since 2011, a tailored, interdisciplinary head and neck rehabilitation (IHNR) program, covered by the basic healthcare insurance, is offered to advanced head and neck cancer (HNC) patients in the Netherlands Cancer Institute (NKI). This program is developed to preserve or restore patients' …

2019-07-03AlgemeenArtikel

Effect of physical exercise on cognitive function and brain measures after chemotherapy in patients with breast cancer (PAM study): protocol of a randomised controlled trial

Witlox, Lenja; Schagen, Sanne B; de Ruiter, Michiel B; Geerlings, Mirjam I; Peeters, Petra H M; Koevoets, Emmie W; van der Wall, Elsken; Stuiver, Martijn (Faculteit Gezondheid); Sonke, Gabe; Velthuis, Miranda J; Palen, Job A M van der; Jobsen, Jan J; May, Anne M; Monninkhof, E M

INTRODUCTION: After treatment with chemotherapy, many patients with breast cancer experience cognitive problems. While limited interventions are available to improve cognitive functioning, physical exercise showed positive effects in healthy older adults and people with mild cognitive impairment. The …

2019-06AlgemeenArtikel

Verkleining van de kans op sepsis na plaatsing goudmarkers

Kyah Bouwman (Student); Anouk Rendering (Student); C. G. M. A. Schillemans (Begeleider)

Voor het bestralen van de prostaat worden goudmarkers geplaatst. De meest voorkomende manier om de goudmarkers te plaatsen is transrectaal. Hiervoor wordt preventief Levofloxacine gegeven om infectieuze complicaties te voorkomen. Echter kunnen Levofloxacine ongevoelige darmbacteriën sepsis veroorzaken. …

2019-05-31GezondheidBachelor

Long-Term Tumor-Free Survival in a Patient with Stage IV Epithelial Ovarian Cancer Undergoing High-Dose Chemotherapy and Viscum album Extract Treatment: A Case Report

Paul G. Werthmann (Onderzoeker); Robert Kempenich (Onderzoeker); Gunver S. Kienle (Onderzoeker)

Epithelial ovarian cancer (EOC) has a poor prognosis in advanced stages. High-dose chemotherapy (HDC) was pursued in the 1990s but was not found to improve survival of patients with EOC in larger studies. Many patients with cancer use Viscum album extracts (VAE). Also called European mistletoe, Viscum …

2019-02-18GezondheidArtikel

Ethical frameworks in lung cancer survival

Krijn van der Burg (Student); Chris Geene (Begeleider)

Van der Burg's study delved into the potential connection between overall survival and patient characteristics, along with radiation dose to the body in lung cancer patients undergoing various treatment schedules. In conclusion, patient characteristics and radiomics data exhibit predictive values for …

2019-01-14ICT & Media; …Stageverslag

Development and validation of a patient decision aid for prostate Cancer therapy

Anshu Ankolekar; Ben G. L. Vanneste; Esther Bloemen-van Gurp (Lid Lectoraat); Joep G. van Roermund; Evert J. van Limbergen; Kees van de Beek; Tom Marcelissen; Victor Zambon; Matthias Oelke; Andre Dekker; Cheryl Roumen; Philippe Lambin (Docent); Adriana Berlanga; Rianne Fijten

Background: Patient decision aids (PDAs) can support the treatment decision making process and empower patients to take a proactive role in their treatment pathway while using a shared decision-making (SDM) approach making participatory medicine possible. The aim of this study was to develop a PDA for …

2019-01-01GezondheidArtikel

Mapping the EORTC QLQ-C30 and QLQ-H&N35 to the EQ-5D for head and neck cancer

Beck, Ann-Jean C C; Kieffer, Jacobien M; Retèl, Valesca P; van Overveld, Lydia F J; Takes, Robert P; van den Brekel, Michiel W M; van Harten, Wim H; Stuiver, Martijn M (Lectoraat Functioneel Herstel Bij Kanker)

INTRODUCTION: Innovations in head and neck cancer (HNC) treatment are often subject to economic evaluation prior to their reimbursement and subsequent access for patients. Mapping functions facilitate economic evaluation of new treatments when the required utility data is absent, but quality of life …

2019AlgemeenArtikel

Radiation dose to the masseter and medial pterygoid muscle in relation to trismus after chemoradiotherapy for advanced head and neck cancer

Sophie A. Kraaijenga; Olga Hamming-Vrieze; Sonja Verheijen; Emmy Lamers (Lid Lectoraat); Lisette van der Molen; Frans J. Hilgers; Michiel W. van den Brekel; Wilma D. Heemsbergen

Abstract Background: We studied the relationship between trismus (maximum interincisor opening [MIO] ≤35 mm) and the dose to the ipsilateral masseter muscle (iMM) and ipsilateral medial pterygoid muscle (iMPM). Methods: Pretreatment and post-treatment measurement of MIO at 13 weeks revealed 17% of …

2019GezondheidArtikel

Exercise is medicine in oncology

Schmitz, Kathryn H; Campbell, Anna M; Stuiver, Martijn M; Pinto, Bernardine M; Schwartz, Anna L; Morris, G Stephen; Ligibel, Jennifer A; Cheville, Andrea; Galvão, Daniel A; Alfano, Catherine M; Patel, Alpa V; Hue, Trisha; Gerber, Lynn H; Sallis, Robert; Gusani, Niraj J; Stout, Nicole L; Chan, Leighton; Flowers, Fiona; Doyle, Colleen; Helmrich, Susan; Bain, William; Sokolof, Jonas; Winters-Stone, Kerri M; Campbell, Kristin L; Matthews, Charles E

Multiple organizations around the world have issued evidence-based exercise guidance for patients with cancer and cancer survivors. Recently, the American College of Sports Medicine has updated its exercise guidance for cancer prevention as well as for the prevention and treatment of a variety of cancer …

2019AlgemeenArtikel

Sarcopenia, a strong determinant for prolonged feeding tube dependency after chemoradiotherapy for head and neck cancer

Karsten, Rebecca T.; Al-Mamgani, Abrahim; Bril, Sandra I.; Tjon-A-Joe, Sheena; van der Molen, Lisette; de Boer, Jan P.; Hilgers, Frans J. M.; Smeele, Ludi E.; van den Brekel, Michiel W. M.; Stuiver, Martijn M.

BACKGROUND: Sarcopenia might be a relevant lead for optimization of the condition of patients with head and neck cancer (HNC) before chemoradiotherapy (CRT) to prevent long-term functional swallowing impairment, such as feeding tube dependency. METHODS: Regression analyses were performed to assess the …

2019AlgemeenArtikel

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