Agent-based modeling (ABM) is a powerful tool for simulating building users’ dynamic behavior in demand response (DR) programs. However, ABM faces several challenges, particularly in encoding building users’ natural language features and common sense into rules or mathematical equations. To overcome …

Agent-based modeling (ABM) is a powerful tool for simulating building users’ dynamic behavior in demand response (DR) programs. However, ABM faces several challenges, particularly in encoding building users’ natural language features and common sense into rules or mathematical equations. To overcome …

Protein kinases function as pivotal regulators in biological events, governing essential cellular processes through the transfer of phosphate groups from ATP molecules to substrates. Dysregulation of kinase activity is frequently associated with cancer, ocasionally arising from chromosomal translocation …

Aims Genetic hypertrophic cardiomyopathy (HCM) is caused by mutations in sarcomere protein-encoding genes (i.e. genotype-positive HCM). In an increasing number of patients, HCM occurs in the absence of a mutation (i.e. genotype-negative HCM). Mitochondrial dysfunction is thought to be a key driver of …

Webontwikkelaars geven aan dat secure coding of het verbeteren van codes een topprioriteit is. Door strakke deadlines en de eis van opdrachtgevers om in korte tijd snel software en uitvoerbare codes aan te leveren, is voor de beveiliging (secure coding) vaak onvoldoende tijd en aandacht. Dit maakt een …

In the operational systems of the Dutch Public Prosecution Service, data about criminal cases are registered. This information is used to generate crime statistics or other management information as input for policymaking. A key element for these statistics is the crime type of a case, which is normally …

From single-cell organisms to complex neural networks, all evolved to provide control solutions to generate context- and goal-specific actions. Neural circuits performing sensorimotor computation to drive navigation employ inhibitory control as a gating mechanism as they hierarchically transform (multi)sensory …

This article describes a relatively straightforward procedure to knock out the gene that encodes the invertase enzyme in baker’s yeast. The SUC2 gene, which encodes for the invertase enzyme, is knocked out by a single-step PCR knock out method. The knockout is subsequently confirmed at the genetic level …

Purpose: Parentally transmitted germ-line chromothripsis (G-CTH) has been identified in only a few cases. Most of these rearrangements were stably transmitted, in an unbalanced form, from a healthy mother to her child with congenital abnormalities probably caused by de novo copy-number changes of dosage …

Video game designers iteratively improve player experience by play testing game software and adjusting its design. Deciding how to improve gameplay is difficult and time-consuming because designers lack an effective means for exploring decision alternatives and modifying a game’s mechanics. We aim to …