Cyclophosphamide (CPA) is a commonly used alkylating chemotherapeutic drug that targets rapidly dividing cells causing apoptosis by crosslinking DNA. While effective against neoplasms, CPA can also affect healthy immune cells. This study investigated whether a single dose of CPA alters healthy lymphoid …

The primary cause of death in breast cancer cases is often metastasis, the spread of cancer cells systemically and the formation of secondary tumors in distant organs of the body. The invasion of breast tumor cells into the surrounding tissue is an initial step in the metastatic cascade. In addition …

Wilms tumour suppressor gene (WT1) is essential for normal development of a kidney, it was also discovered as a major controller of mesenchymal-epithelial balance in general development of organs. In this project we use Wt1 and its role in the mesenchymal-epithelial balance to study the mechanism of …

The Department of Pathobiology of the Veterinary Faculty at the University of Utrecht is investigating the causes of the death of stranded porpoises. The causes of death of porpoises are assessed by internal and external investigation at the Utrecht University. At dissections, the organs of the dead …

PRRT is a method of treatment that is used for a variety of diseases. In this method of treatment patient are infused with a radiopharmaceutical. This radiopharmaceutical will deliver a radiation dose to the specific targeted organ. However, due to infusion in the bloodstream other organs will also sustain …

Over the past decades, international terrorism started to reach its ideological peak, challenging and disrupting whole societies and governmental organs. This modern form of terror contains violent implications, psychologically pressing the innocent masses. Initially inspired by occasional, domestically …

The severe shortage of donors is a major constraint facing European countries. In Europe more than 60,000 patients are on waiting lists for an organ transplantation. Because of the shortage of donated organs, every day almost ten people die in Europe while on the waiting list. But what are the causes …