Objective To determine the association between physical activity (PA; duration and intensity) and patient and clinical outcomes at various measurement occasions post dysvascular major lower limb amputation (LLA). Methods In this multicenter longitudinal observational study, the PA levels of adults who …

In nature, resources necessary for reproduction and survival are often spatially distributed or scarce. Parasitoid wasps are insects that develop as larvae in or on a single invertebrate resource (often another insect), while the adults are free-living and rely on carbohydrates, for example, floral nectar, …

Clinical outcomes in ROS1-fusion positive (ROS1+) non-small cell lung cancer (NSCLC) by fusion partner and resistance mechanisms are limited. This cohort study included 56 ROS1+ patients (FISH or NGS confirmed); fusion partners were identified in 27 cases, including CD74 (n = 10), EZR (n = 7), and SDC4 …

This study examines the role of host inflammation in the high mortality of tuberculous meningitis (TBM) and identifies potential biomarkers associated with improved survival. We conducted a case-control study involving 131 patients in a discovery cohort, 81 TBM patients in a validation cohort, and 43 …

Multi-layer cell constructs produced in vitro are an innovative treatment option to support the growing demand for therapy in regenerative medicine. Our research introduces a novel construct integrating organ-derived decellularised extracellular matrix (dECM) hydrogels and 3D-printed biodegradable polymer …

Since 2012, the harbor seal (Phoca vitulina) population in the Dutch Wadden Sea has been in decline, raising concerns about the potential role of infectious diseases. Historical outbreaks like those caused by Phocine Distemper Virus (PDV) and Influenza A virus subtype H10N7, have shown that pathogens …

SMEs often operate with limited technical expertise and constrained budgets, making it difficult to implement comprehensive cybersecurity measures. Yet, these businesses play a critical role in the Dutch economy, employing over 70% of the working population and contributing €309 billion annually. Ensuring …

Onder- en overvoeding op Intensive Care-afdelingen (IC's) wordt in verband gebracht met een langere ziekenhuisopname, een verhoogde morbiditeit en een verhoogde mortaliteit, en een verhoogde mortaliteit. Deze studie onderzoekt of IC-patiënten optimaal gevoed werden volgens de European Society voor Klinische …

Chapter 1: General introduction. A specific group of people with disabilities includes individuals with profound intellectual and multiple disabilities (PIMD). However, individuals with PIMD form a heterogeneous group regarding the origins of their underlying conditions leading to profound disabilities …

Purpose: To our knowledge, there have been no comparative studies evaluating the associations of frailty defined using the Tilburg Frailty Indicator (TFI), frailty phenotype by Fried et al, and FRAIL scale with all-cause mortality in Turkiye. In this study, we aimed to evaluate the ability of these instruments …