In times of profound technological and societal change, the capacity of family firms to innovate is critical for both performance and long-term survival. Yet innovation research often emphasizes observable outcomes, obscuring the organizational abilities that enable sustained innovation across generations. …

In an increasingly globalized world challenged by multiple social problems, global social identifications (GSIs, e.g., with all humanity) are concepts of growing interest. Although such identifications can be affected by the cultural contexts in which they are manifested, research on them remains largely …

Rationale Up to 60% of patients with head and neck cancer are malnourished upon first presentation. Malnutrition has been associated with a higher risk of adverse events and decreased quality of life and survival. Patients with a high risk of malnutrition often receive pretreatment dietary treatment …

RNA metabolism is governed by RNA-binding proteins (RBPs), which regulate gene expression in cells, including immune system cells. Cells overcome stressing factors to ensure survival by employing a wide range of mechanisms that mitigate damage and restore homeostasis. One of the mechanisms is the formation …

Clinical outcomes in ROS1-fusion positive (ROS1+) non-small cell lung cancer (NSCLC) by fusion partner and resistance mechanisms are limited. This cohort study included 56 ROS1+ patients (FISH or NGS confirmed); fusion partners were identified in 27 cases, including CD74 (n = 10), EZR (n = 7), and SDC4 …

This study examines the role of host inflammation in the high mortality of tuberculous meningitis (TBM) and identifies potential biomarkers associated with improved survival. We conducted a case-control study involving 131 patients in a discovery cohort, 81 TBM patients in a validation cohort, and 43 …

Multi-layer cell constructs produced in vitro are an innovative treatment option to support the growing demand for therapy in regenerative medicine. Our research introduces a novel construct integrating organ-derived decellularised extracellular matrix (dECM) hydrogels and 3D-printed biodegradable polymer …

Oyster reefs were once abundant in European waters, but they are now rare. In Zeeland, the wild population of the native flat oyster (Ostrea edulis) has declined significantly in recent decades, with serious implications for coastal water health in relation to biodiversity and water quality (Colsoul …

Since 2012, the harbor seal (Phoca vitulina) population in the Dutch Wadden Sea has been in decline, raising concerns about the potential role of infectious diseases. Historical outbreaks like those caused by Phocine Distemper Virus (PDV) and Influenza A virus subtype H10N7, have shown that pathogens …

SMEs often operate with limited technical expertise and constrained budgets, making it difficult to implement comprehensive cybersecurity measures. Yet, these businesses play a critical role in the Dutch economy, employing over 70% of the working population and contributing €309 billion annually. Ensuring …