Cardamonin is a natural chalcone that has been extensively investigated for its anticancer activity. However, its clinical relevance is still not explicit, limiting its progression into clinical trials and highlighting a persistent gap between preclinical evidence and practical application. This review …

The NANOSPRESSO project is a pioneering response to the complex challenge of treating orphan diseases, which, despite affecting millions of people globally, have only scant therapeutic options. This initiative represents a paradigm shift by decentralizing the production of personalized nucleic acid nanomedicines. Integrating …

Neck pain is a common condition that hinders people's daily functioning. The care of people with non-specific neck pain requires a personalised biopsychosocial approach. However, integrating psychological factors in therapeutic interventions remains a challenge. Understanding psychological mechanisms …

‘Flow, a journey of wellness and nature’ is composed of three parts. It starts with a visitor center at the edge of the nature reserve Maashorst, near the highway. A cycling and walking route leads to a gate platform, from where a raised path leads to a wellness pavilion and an outdoor terrace. The orchestration …

This article reports the findings of focus-group discussions with healthcare providers concerning the facilitators and barriers they experience when engaging in therapeutic patient education (TPE). Methods: Five focus-group discussions were held with a total of 21 primary and secondary healthcare providers. Discussions …

Hyperhomocysteinemia is a risk factor for cardiovascular disease, neurological disorders, and bone abnormalities. The key enzyme in homocysteine metabolism, cystathionine-β-synthase (CBS) is recognized as a target for new homocysteine-lowering therapies including enzyme replacement and gene therapy. …

Equine-Assisted Services (EAS) offer many benefits for people with intellectual or physical disabilities. As these services grow in popularity, ensuring the welfare of the horses involved is crucial. This study explored the horses’ mood state during equine-assisted coaching and therapeutic riding sessions, …

Background Goal setting is an essential step in the clinical reasoning process of speech and language therapists (SLTs) who provide care for children, adolescents and adults with communication disorders. In the light of person-centred care, shared or collaborative goal setting between the SLT and client …

Objective To investigate whether duration of knee symptoms influenced the magnitude of the effect of exercise therapy compared to non-exercise control interventions on pain and physical function in people with knee osteoarthritis (OA). Method We undertook an individual participant data (IPD) meta-analysis …

Abstract Background Despite eforts to improve undergraduate clinical pharmacology & therapeutics (CPT) education, prescribing errors are still made regularly. To improve CPT education and daily prescribing, it is crucial to understand how therapeutic reasoning works. Therefore, the aim of this study …