HBO Kennisbank

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Zocht je misschien: biomarkers?

IL-6, calcium, salivary amylase activity and cortisol as a salivary biomarker-combination associated with obesity: a pilot study

H. Al Habobe (Onderzoeker); E. B. Haverkort (Onderzoeker); K. Nazmi; L. K. Van Nieukerken; V. E. A. Gerdes; F. J. Bikker; R. H. H. Pieters (Lector)

Introduction: As obesity continues to escalate to pandemic levels worldwide, innovative approaches for early diagnosis, risk stratification, and disease monitoring are urgently needed. Saliva presents a promising non-invasive method for biomarker-based screening in obesity. Objective: This study aimed …

2026GezondheidArtikel

Investigating the salivary biomarker profile in obesity: a systematic review

H. AL Habobe (Onderzoeker); R. H.H. Pieters (Lector); F. Bikker

Salivary biomarkers hold promise as non-invasive indicators of obesity-related metabolic dysfunction, particularly in MUO. However, their clinical diagnostic utility remains uncertain due to heterogeneity in study designs, a lack of biomarker validation, and limited longitudinal studies. Further research …

2025GezondheidArtikel

The impact of saliva collection methods on measured salivary biomarker levels

Hanan al Habobe (Onderzoeker); Liesbeth Haverkort (Onderzoeker); Kamran Nazmi (Onderzoeker); Annina van Splunter (Onderzoeker); Raymond Pieters (Lector); Floris Bikker (Onderzoeker)

Saliva diagnostics have become increasingly popular due to their non-invasive nature and patient-friendly collection process. Various collection methods are available, yet these are not always well standardized for either quantitative or qualitative analysis. In line, the objective of this study was …

2024GezondheidArtikel

The impact of saliva collection methods on measured salivary biomarker levels

H. Al Habobe (Onderzoeker); E.B. Haverkort (Onderzoeker); K. Nazmi; A.P. van Splunter; R.H.H. Pieters (Lector); F.J. Bikker

2024GezondheidArtikel

Sex differences in the association between dual-energy x-ray absorptiometry-measured body composition and periodontitis

Zhu, Peijun; Li, An; Cai, Qingqing; Chen, Yuntao; Liu, Yang; Jager-Wittenaar, Harriët (Malnutrition And Healthy Ageing); Tjakkes, Geerten-Has; Xu, Shulan

Background: A positive association between obesity based on body mass index (BMI) and periodontitis has been reported. Fat tissue-related systemic inflammation acts as the link to periodontal comorbidities of obesity. However, the BMI is unable to distinguish fat and fat-free tissues. More precise measures …

2023-08-28Gezondheid; …Artikel

Nailfold capillaroscopy and candidate-biomarker levels in systemic sclerosis-associated pulmonary hypertension

Lemmers, Jacqueline; van Caam, Arjan; Kersten, Brigit E.; van den Ende, Cornelia; Knaapen, Hanneke; van Dijk, Arie; Hagmolen of Ten Have, Wanda; van den Hoogen, Frank; Koenen, Hans J P M; van Leuven, Sander; Alkema, Wynand; Smeets, Ruben L; Vonk, Madelon C.

Objectives: Pulmonary hypertension is one of the leading causes of death in systemic sclerosis. Early detection and treatment of pulmonary hypertension in systemic sclerosis is crucial. Nailfold capillaroscopy microscopy, vascular autoantibodies AT1R and ETAR, and several candidate-biomarkers have the …

2023-05-22AlgemeenArtikel

Innovation4Health

Alkema, Wynand

Wynand Alkema vertelt over het gebruik van ChatGPT in het ontwikkelen van nieuwe medicijnen. Een samenvatting van het praatje is hieronder weergegeven:The FAIR use of Large Language Models in the drug development pipeline.With the emergence of applications that are based on large language models (LLMs), …

2023-04-06AlgemeenConferentiebijdrage

Optimal Dosing and Timing of High-Dose Corticosteroid Therapy in Hospitalized Patients With COVID-19

Daenen, Katrijn; Huijben, Jilske A; Boyd, Anders; Bos, Lieuwe D J; Stoof, Sara C M; van Willigen, Hugo; Gommers, Diederik A M P J; Moeniralam, Hazra S; den Uil, Corstiaan A; Juffermans, Nicole P; Kant, Merijn; Valkenburg, Abraham J; Pillay, Janesh; van Meenen, David M P; Paulus, Frederique (Lectoraat Critical Care); Schultz, Marcus J; Dalm, Virgil A S H; van Gorp, Eric C M; Schinkel, Janke; Endeman, Henrik

Background: In hospitalized patients with COVID-19, the dosing and timing of corticosteroids vary widely. Low-dose dexamethasone therapy reduces mortality in patients requiring respiratory support, but it remains unclear how to treat patients when this therapy fails. In critically ill patients, high-dose …

2023-01AlgemeenArtikel

Salivary concentrations of secretory leukocyte protease inhibitor and matrix metallopeptidase-9 following a single bout of exercise are associated with intensity and hydration status

Karen Knipping (Onderzoeker); Shirley Kartaram (Onderzoeker); Marc Teunis (Onderzoeker); Nicolaas Zuithoff (Onderzoeker); Nicole Buurman (Onderzoeker); Laura M'Rabet (Onderzoeker); Klaske van Norren (Onderzoeker); Renger Witkamp (Onderzoeker); Raymond Pieters (Lector); Johan Garssen (Onderzoeker)

Aim: To investigate the effects of exercise on salivary concentrations of inflammatory markers by analyzing a panel of 25 inflammatory markers in subjects who had participated in bicycle ergometer tests varying in workload and hydration status. Methods: Fifteen healthy young men (20-35 years) had performed …

2023GezondheidArtikel

Cartilage tissue turnover increases with high- compared to low-intensity resistance training in patients with knee OA

Thudium, Christian S.; Engstrøm, Amalie; Bay-Jensen, Anne Christine; Frederiksen, Peder; Jansen, Nuria; De Zwart, Arjan; van der Leeden, Marike; Dekker, Joost; Lems, Willem; Roorda, Leo; van Spil, Willem Evert; Van der Esch, Martin (Lectoraat Interdisciplinaire Zorg Voor Chronische Gewrichtsaandoeningen)

Objectives To investigate cartilage tissue turnover in response to a supervised 12-week exercise-related joint loading training program followed by a 6-month period of unsupervised training in patients with knee osteoarthritis (OA). To study the difference in cartilage tissue turnover between high- and …

2023AlgemeenArtikel

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