Obesity is a growing global burden with numerous significant health implications, including a higher risk of developing Alzheimer’s disease (AD). This study investigates the role of obese adipose tissue on AD pathology in male APPswe/PSEN1-dE9 (APP/PSEN-1) transgenic mice, with a focus on cognitive decline, …

Brain disorders, such as Alzheimer’s disease and epilepsy have been linked to an imbalance in excitatory and inhibitory (E/I) inputs in the brain. However, the molecular mechanisms underlying E/I balance and plasticity in the brain are largely unresolved. Inhibitory synapses have a strong impact on brain …

Alzheimer's disease is a complex neurodegenerative disease and the most prevalent form of dementia. It affects every 14th person after the age of 65, thus making it a serious concern in modern society. Furthermore, currently available treatment is restricted only to symptomatic and is not highly effective. …

Animal wellbeing is important and it is widely accepted that an animal’s basic needs must be fulfilled. Many factors affect wellbeing of dairy cows. Common health problems are lameness and subclinical mastitis. The aim of this study was to examine changes in proximity and automatic milk system (AMS) …

This research paper was written for [Company] which is a start-up company from Delft, The Netherlands. [Company] has developed an innovative new product in the MedTech industry which uses robotics and AI to deliver an autonomous Transthoracic Echocardiogram (an ultrasound scan of the heart). [Company] …

What is the comparative analysis between individuals with idiopathic parkinson's disease and both young and elderly healthy individuals in completing a modified 10-meter walk test with visual stroop tasks?

Doel van deze studie was inzicht krijgen in de huidige adolescenten-patiëntenpopulatie met M.Crohn (CD) en Colitis Ulcerosa (UC) van diagnose (vanaf 1-1-2005) tot één jaar na transitie, van Kindergeneeskunde naar de volwassen MDL-zorg binnen het Zuyderland Medisch Centrum. Hiermee beogen we een bijdragen …

Arrhythmogenic Cardiomyopathy (ACM), also known as arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D) is a rare hereditary disease of the heart, where the connective, and fatty tissue is deposited in the muscle tissue of the ventricular myocardium primarily of the right but also left …

Alzheimer's disease (AD) is the common neurodegenerative disorder and the most frequent cause of dementia. The disease accounts around 80% of all dementia diagnoses. The main reason of developing AD is amyloid cascade which starts from missense mutations in APP (amyloid precursor protein), Rho-associated …

Inleiding Boksen als interventie voor Parkinsonpatiënten is veelbelovend gebleken en heeft positieve effecten op evenwicht, gang, dagelijkse activiteiten en de algehele kwaliteit van leven. Daarbij is uit eerdere onderzoeken gebleken dat boksen als interventie positieve effecten heeft op verschillende …